Rat oligodendrocytes express the vitamin D3 receptor and respond to 1,25-dihydroxyvitamin D3

Baas, Dominique; Prüfer, Kirsten; Ittel, Marie Elisabeth; Kuchler‐Bopp, Sabine; Labourdette, G.; Sarliève, Louis L.; Brachet, Philippe

doi:10.1002/(sici)1098-1136(200007)31:1<59::aid-glia60>3.0.co;2-y

Cited by 125 publications

(90 citation statements)

References 81 publications

(79 reference statements)

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“…1, 25(OH) 2 D 3 also enhances innate antioxidant pathways. The hormone upregulates gamma glutamyl transpeptidase (Baas, Prufer et al 2000) and subsequently increases glutathione. Glutathione is an innate antioxidant which protects oligodendrocytes and the integrity of the nerve conduction pathway critical to mental processing.…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

306

220

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Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

306

220

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“…The VDR has been identified in most nucleated cells of the body, involved in countless physiological functions (Walters, 1992). VDRcontaining cells, in autoimmune diseases, include b-cells in the pancreas in insulin-dependent diabetes mellitus (IDDM), chondrocytes in the joints in rheumatoid arthritis (RA), and oligodendrocytes in the brain in MS (Casteels et al, 1995;Baas et al, 2000;DeLuca & Cantorna, 2001). In parallel to oligodendrocytes, other CNS constituent cells (microglia, neurons, and astrocytes) are VDR-expressing cells responding directly to the hormone (Garcion et al, 2002).…”

Section: Vitamin D Receptor (Vdr)mentioning

confidence: 99%

Multiple sclerosis and vitamin D: an update

et al. 2004

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MS is a chronic, immune-mediated inflammatory and neurodegenerative disease of the central nervous system (CNS), with an etiology that is not yet fully understood. The prevalence of MS is highest where environmental supplies of vitamin D are lowest. It is well recognized that the active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25-(OH) 2 D), is a natural immunoregulator with anti-inflammatory action. The mechanism by which vitamin D nutrition is thought to influence MS involves paracrine or autocrine metabolism of 25OHD by cells expressing the enzyme 1a-OHase in peripheral tissues involved in immune and neural function. Administration of the active metabolite 1,25-(OH) 2 D in mice and rats with experimental allergic encephalomyelitis (EAE, an animal model of MS) not only prevented, but also reduced disease activity. 1,25-(OH) 2 D alters dendritic cell and T-cell function and regulates macrophages in EAE. Interestingly, 1,25-(OH) 2 D is thought to be operating on CNS constituent cells as well. Vitamin D deficiency is caused by insufficient sunlight exposure or low dietary vitamin D 3 intake. Subtle defects in vitamin D metabolism, including genetic polymorphisms related to vitamin D, might possibly be involved as well. Optimal 25OHD serum concentrations, throughout the year, may be beneficial for patients with MS, both to obtain immune-mediated suppression of disease activity, and also to decrease disease-related complications, including increased bone resorption, fractures, and muscle weakness.

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“…Studies have also shown that VDR transcripts exist in rat oligodendrocytes, and VDR-positive cells were present in brain white matter [5]. Vitamin D 3 increased the amount of transcripts coding for its own receptor, VDR, and also for NGF, further confirming a role in neurogenesis and protection [5].…”

Section: Introductionmentioning

confidence: 93%

“…The vitamin D 3 receptor (VDR) has been identified in brain and spinal cord neurons of developing fetal rats [2,3,4], indicating that vitamin D 3 must have some role in neurogenesis. Furthermore, vitamin D 3 has been found to have a neuroprotective effect, as it regulates the production of nerve growth factor (NGF) and the expression of other neurotrophins [5]. Studies have also shown that VDR transcripts exist in rat oligodendrocytes, and VDR-positive cells were present in brain white matter [5].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, vitamin D 3 has been found to have a neuroprotective effect, as it regulates the production of nerve growth factor (NGF) and the expression of other neurotrophins [5]. Studies have also shown that VDR transcripts exist in rat oligodendrocytes, and VDR-positive cells were present in brain white matter [5]. Vitamin D 3 increased the amount of transcripts coding for its own receptor, VDR, and also for NGF, further confirming a role in neurogenesis and protection [5].…”

Section: Introductionmentioning

confidence: 99%

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