Rat Mastoid Bullae Obliteration with Hydroxyapatite: Histopathologic Results with Various Size of Hydroxyapatite

Kim, So-Hyang; Park, Jung-Hong; Kim, Soojin; Kang, Myeong Jin; Kang, Myung-Koo

doi:10.3342/kjorl-hns.2010.53.4.209

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…The pore size of the commercial porous HA (Bongros; Daewoong Pharmaceutical Co. Ltd., Seongnam, Korea) was 300 μm, but the mixed graft material changed to a powder form during the stirring process; thus, the particle size and pore size may have decreased. In a study that evaluated the amount of new bone formation after applying various particle sizes of HA to temporal bullae in rats, larger HA particles were associated with faster new bone formation rates [ 26 ]. This finding explains why the rate of new bone formation was lower in this experiment when using a sample with smaller particle size than the rate reported in our previous study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

Lee

Bark

Quy

et al. 2018

IJMS

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The regeneration of bone defects caused by periodontal disease or trauma is an important goal. Porous hydroxyapatite (HA) is an osteoconductive graft material. However, the hydrophobic properties of HA can be a disadvantage in the initial healing process. HA can be coated with TiO2 to improve its hydrophilicity, and ultraviolet irradiation (UV) can further increase the hydrophilicity by photofunctionalization. This study was designed to evaluate the effect of 5% TiO2-coated HA on rabbit calvarial defects and compare it with that of photofunctionalization on new bone in the early stage. The following four study groups were established, negative control, HA, TiO2-coated HA, and TiO2-coated HA with UV. The animals were sacrificed and the defects were assessed by radiography as well as histologic and histomorphometric analyses. At 2 and 8 weeks postoperatively, the TiO2-coated HA with UV group and TiO2-coated HA group showed significantly higher percentages of new bone than the control group (p < 0.05). UV irradiation increased the extent of new bone formation, and there was a significant difference between the TiO2-coated HA group and TiO2-coated HA with UV group. The combination of TiO2/HA and UV irradiation in bone regeneration appears to induce a favorable response.

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Section: Discussionmentioning

confidence: 99%

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

Lee

Bark

Quy

et al. 2018

IJMS

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“…At 12 weeks after the tympanic bulla obliteration surgery, the animals were sacrificed as in other previous studies for radiological and histological analysis. 6,9,13 2.7. Mastoidectomy and Obliteration Procedures.…”

Section: Methodsmentioning

confidence: 99%

“…The Sham group was not treated with any reagents or materials. At 12 weeks after the tympanic bulla obliteration surgery, the animals were sacrificed as in other previous studies for radiological and histological analysis. ,, …”

Section: Methodsmentioning

confidence: 99%

“…However, these grafts present limitations including insufficient amounts of autologous grafts, the presence of defects in donor sites, and graft reabsorption after surgery . To overcome these limitations, alloplastic materials, including silicon, calcium phosphate ceramics, optical fibers, and various artificial materials, have been developed. ,− In particular, hydroxyapatite (HAp), as a unique natural ceramic with similarities to human bone, is recognized as a suitable implant material owing to its biostability, biocompatibility, and osteoconductivity. , Sun et al developed a unique multilayered HAp-chitosan patch by a sublimation-assisted compression (SAC) process, which demonstrated the ability to promote cell proliferation, cell differentiation, and reproduction of an osteoblast culture in vitro .…”

Section: Introductionmentioning

confidence: 99%

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Human Tonsil-Derived Mesenchymal Stem Cells-Loaded Hydroxyapatite-Chitosan Patch for Mastoid Obliteration

Choi

Kang

Caifeng

et al. 2020

ACS Appl. Bio Mater.

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Canal wall down (CWD) mastoidectomy is a surgical procedure that is essential to eradicate chronic ear diseases but results into bone defects due to the resulting mastoid cavity. This study investigated the ability of human tonsil-derived mesenchymal stem cells (hTMSCs) combined with a hydroxyapatite (HAp)-chitosan patch to promote osteogenesis in the treatment of postoperative temporal bone defects using an animal model. At 12 weeks postsurgery, the obliteration ratio and bone formation in the tympanic bulla of rats that were grafted with hTMSCs and a hydroxyapatite (HAp)-chitosan patch or not were compared using histopathological observation and computed tomography (CT) imaging. The group of rats that was administered the Patch group and the group of rats that was administered hTMSCs + Patch group both showed significantly remarkable obliteration ratios and bone formation compared with the Sham and hTMSCs groups. Moreover, the hTMSCs + Patch group showed bone formation in both the periphery and the central region of the tympanic bulla cavity, indicating prominently enhanced osteogenesis compared to the Patch group. Altogether, the results showed that combining hTMSCs with a HAp-chitosan patch accelerated osteogenesis for reconstruction of postoperative temporal bone defects. These findings demonstrate that the hTMSCs + Patch scaffolds are promising for treatment of the bone defects in the tissue engineering.

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Rat Mastoid Bullae Obliteration with Hydroxyapatite: Histopathologic Results with Various Size of Hydroxyapatite

Cited by 2 publications

References 14 publications

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

Human Tonsil-Derived Mesenchymal Stem Cells-Loaded Hydroxyapatite-Chitosan Patch for Mastoid Obliteration

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