Rat Genetic Strain Differences In Right Ventricular Remodeling In Response To Hypoxia-Induced Pulmonary Hypertension

Reply to Bogaard et al.: Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension

“…In addition, there are substantial differences between Wistar and WKY rats. As reported previously, WKY rats are more prone to inflammation in comparison to Wistar and SD rat strains when exposed to hypoxia (12). It could at least partially contribute to the more prominent emphysema phenotype in WKY in comparison with SD rats in response to SuHx.…”