Rat gastric secretion following acute exposure to nicotine

Thompson, John N.; Brückner, W. L.

doi:10.1016/0014-2999(70)90310-9

Cited by 18 publications

(3 citation statements)

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“…In agreement with Thompson and Bruckner [20] acute treatment of rats with NHT inhibited output of HC1 and pepsin in nonstimulated rats. We found, however, that in such rats NHT also induced depression in concentra tion of acid and pepsin.…”

Section: Discussionsupporting

confidence: 74%

“…With ICI-50123 (pentapeptide)-stimulated secretion, nicotine depressed only pepsin output [19]. The concentrations of HC1 and pepsin were not discussed in these studies [19,20]. Thompson et al [21] also reported on chronic effects of nicotine on rat gastric secretion.…”

mentioning

confidence: 90%

“…Gastric secretion in rats, following exposure to nicotine, was first stud ied by T hompson and Bruckner [20]. They injected nicotine hydrogen tar trate into pylorus-ligated rats, using a 2-hour collection period, and found a significant depression in the output of HC1 and pepsin.…”

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confidence: 99%

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Effect of Nicotine Hydrogen Tartrate on Gastric Secretion of Normal and Vagotomized Rats Stimulated with Histamine Pentagastrin and Bethanechol Chloride

Kowalewski¹

1974

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Effect of acute and chronic treatment with nicotine hydrogen tartrate (NHT), on gastric secretion, was assessed in intact and vagotomized rats bearing permanent gastric fistulas. Intravenous infusion of NHT for 24 h with simultaneous collection of gastric juice demonstrated the inhibitory action of this drug on basal secretion and secretion stimulated with histamine, pentagastrin, and bethanechol chloride. Inhibition affected output of HC1 and pepsin and concentration of HC1. In nonstimulated and in bethanechol-stimulated rats, NHT also decreased the concentration of pepsin. Chronic treatment of rats with NHT also induced the inhibition of gastric secretion under various stimulation conditions. Inhibitory action of NHT on gastric secretion was also observed in vagotomized rats stimulated by secretagogues used in this study.

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Section: Discussionsupporting

confidence: 74%

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confidence: 90%