Rat endogenous pyrogen and fever

Morimoto, Akio; Watanabe, Tatsuo; Ono, Takuya; Sakata, Yoshiyuki; Murakami, Naotoshi

doi:10.1152/ajpregu.1986.250.5.r776

Cited by 16 publications

(13 citation statements)

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“…Many reports using the recombinant human IFNs have clarified that IFN-y is one of the endogenous mediators responsible for fever and acute phase response as well as IL-1, TNF and IL-6 [22,23,27]. Our correlative study of fever and IFN-y levels may raise the possibility that high titres of IFN-y perform ant• activity, acting as one of the endogenous pyrogens secreted during the acute phase of aseptic meningitis [17,30].…”

Section: Comparison Between Ifn-) Level In Csf and Clinical~laboratomentioning

confidence: 84%

Aseptic meningitis in children: Correlation between fever and interferon-gamma level

et al. 1991

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We studied the correlation between interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) in cerebrospinal fluid (CSF) and clinical/laboratory findings in children with aseptic meningitis. In 19/27 patients (70%), the CSF IFN level was high at initial diagnosis, and reduced to a low or undetectable level during the convalescent phase (5-14 days later) of the disease. There were no differences in IL-1 beta and TNF-alpha levels between the acute and convalescent phase of the patients. The serum IFN-gamma levels in the patients, which were simultaneously examined were undetectable in the acute phase. When we compared the clinical/laboratory findings between the 29 patients with detectable CSF IFN-gamma level and the 21 patients with an undetectable CSF IFN-gamma level in the acute phase, the former demonstrated higher body temperature (P less than 0.01), and higher cell number and protein level in the CSF (P less than 0.05) than the latter. On the other hand, there were no significant differences in the duration of meningeal signs, the titre of C-reactive protein, and the peripheral leucocyte count between the two groups. By the Spearman's rank sum test, the CSF IFN-gamma levels correlated more definitively with the severity of febrile episode (maximal body temperature, duration of fever and body temperature at the first lumbar tap), and the cell number and protein level in the CSF. These results suggest that IFN-gamma produced in the inflamed intrathecal space may be associated with the pathogenesis of aseptic meningitis, especially the production of fever.

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Section: Comparison Between Ifn-) Level In Csf and Clinical~laboratomentioning

confidence: 84%

Aseptic meningitis in children: Correlation between fever and interferon-gamma level

et al. 1991

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“…(Morimoto et al 1986). Considering that the molecular weight of IFN-y is almost the same as that of endogenous pyrogen (IL-1) (Dinarello, 1984), it is suggested that IFN-y induces the fever by both peripheral and central actions, as does endogenous pyrogen (IL-1).…”

Section: Discussionmentioning

confidence: 99%

Fever and acute phase response induced in rabbits by human recombinant interferon‐gamma.

Morimoto

Murakami

Takada

et al. 1987

The Journal of Physiology

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SUMMARY1. Intravenous (i.v.) and intracerebroventricular (I.c.v.) injections of human recombinant interferon-y (IFN-y) produced dose-dependent fevers in rabbits. The fever induced by i.v. injection was monophasic and the maximum elevation occurred 80-110 min after injection. The fever induced by i.c.v. injection was observed from about 20 min after injection and was remarkably prolonged over 4 h.2. The development of pyrogenic tolerance to IFN-y was observed when rabbits were given i.v. injections on 3 successive days. Furthermore, the pyrogenicity of IFN-y was significantly attenuated by heating at 60 'C for 40 min. The i.v. injection of IFN-y enhanced the febrile response induced by endotoxin but had no effect on that induced by endogenous pyrogen.3. The i.v. injection of a large dose of IFN-y (6 x 106 units/kg) induced an acute phase response, which included a reduction in plasma concentration of iron and zinc.4. The present results suggest that IFN-y released from lymphocytes is one of the endogenous mediator proteins responsible for producing fever and acute phase response.

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“…The leucocytes were stimulated by a lipopolysaccharide of Salmonella typhosa endotoxin (Difco). The general procedures for preparing endogenous pyrogen have been previously described (Morimoto, Watanabe, Ono, Sakata & Murakami, 1986). Partial purification was effected by ultrafiltration using two types of membranes (lOYMIO, 1OXM50, Amicon), which removed all substances of molecular weight outside the range of 10000-50000.…”

Section: Methodsmentioning

confidence: 99%

Brain regions involved in the development of acute phase responses accompanying fever in rabbits.

Morimoto

Murakami

Nakamori

et al. 1989

The Journal of Physiology

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SUMMARY1. The effects of microinjection of rabbit endogenous pyrogen and human recombinant interleukin-la on rectal temperature and acute phase responses were extensively examined in forty different brain regions of rabbits. The acute phase responses that were investigated were the changes in plasma levels of iron, zinc and copper concentration and the changes in circulating leucocyte count.2. The rostral hypothalamic regions, such as nucleus broca ventralis, preoptic area and anterior hypothalamic region, responded to the microinjection of endogenous pyrogen or interleukin-1 by producing both fever and acute phase responses.3. The microinjection of endogenous pyrogen or interleukin-1 into the rostral hypothalamic regions significantly decreased the plasma levels of iron and zinc concentration 8 and 24 h after injection. The circulating leucocyte count increased 8 h after injection. However, neither the injections of endogenous pyrogen nor interleukin-1 affected the number of red blood cells.4. The present results show that the rostral hypothalamic regions respond directly to endogenous pyrogen or interleukin-1 with the consequent development of fever and acute phase responses.

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Rat endogenous pyrogen and fever

Cited by 16 publications

References 0 publications

Aseptic meningitis in children: Correlation between fever and interferon-gamma level

Aseptic meningitis in children: Correlation between fever and interferon-gamma level

Fever and acute phase response induced in rabbits by human recombinant interferon‐gamma.

Brain regions involved in the development of acute phase responses accompanying fever in rabbits.

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