Rat Carotid Artery Responses to α‐Adrenergic Receptor Agonists and 5‐HT After Ovariectomy and Hormone Replacement

Mehrotra, Swati; Gupta, Saurabh; Villalón, Carlos M.; Boomsma, Frans; Saxena, Pramod R.; MaassenVanDenBrink, Antoinette

doi:10.1111/j.1526-4610.2006.00530.x

Cited by 10 publications

(11 citation statements)

References 60 publications

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“…It is possible that Y 1 mechanisms are dependent on the type of tissue (red or white muscle) or blood vessel under study. Our results are consistent with other in vitro studies that failed to detect a difference in sympathetic (adrenergic) vasoconstriction following estradiol supplementation (3,29,42). Y 1 -receptor activation can induce a moderate amount of vasoconstriction in isolated first-order arterioles of young adult female rats, and long-term estradiol supplementation does not impact Y 1 -receptor sensitivity in these vessels.…”

Section: Discussionsupporting

confidence: 95%

“…The absence of an estradiol effect on sympathetic neurotransmission is not unprecedented with similar null results having been observed in adrenergic vasoconstriction (3,22,29,42). Estradiol supplementation over a wide range of treatment durations (ϳ1-60 days) did not alter the adrenergic postjunctional response in female rats (3,29,42).…”

Section: Discussionsupporting

confidence: 69%

“…Estradiol supplementation over a wide range of treatment durations (ϳ1-60 days) did not alter the adrenergic postjunctional response in female rats (3,29,42). The effects of estradiol supplementation on NPY-mediated vasoconstriction are less clear and have received little attention.…”

Section: Discussionmentioning

confidence: 86%

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Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

Evanson

Stone

Samraj

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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The effects of estradiol on neuropeptide Y (NPY) neurotransmission in skeletal muscle resistance vessels have not been described. The purpose of this study was to determine the effects of long-term estradiol supplementation on NPY overflow, degradation, and vasoconstriction in gastrocnemius first-order arterioles of adult female rats. Female rats (4 mo; n = 34) were ovariectomized (OVX) with a subset ( n = 17) receiving an estradiol pellet (OVE; 17β-estradiol, 4 μg/day). After conclusion of the treatment phase (8 wk), arterioles were excised, placed in a physiological saline solution (PSS) bath, and cannulated with micropipettes connected to albumin reservoirs. NPY-mediated vasoconstriction via a Y1-agonist [Leu31Pro34]NPY decreased vessel diameter 44.54 ± 3.95% compared with baseline; however, there were no group differences in EC50(OVE: −8.75 ± 0.18; OVX: −8.63 ± 0.10 log M [Leu31Pro34]NPY) or slope (OVE: −1.11 ± 0.25; OVX: −1.65 ± 0.34% baseline/log M [Leu31Pro34]NPY). NPY did not potentiate norepinephrine-mediated vasoconstriction. NPY overflow experienced a slight increase following field stimulation and significantly increased ( P < 0.05) over control conditions in the presence of a DPPIV inhibitor (diprotin A). Estradiol status did not affect DPPIV activity. These data suggest that NPY can induce a moderate decrease in vessel diameter in skeletal muscle first-order arterioles, and DPPIV is active in mitigating NPY overflow in young adult female rats. Long-term estradiol supplementation did not influence NPY vasoconstriction, overflow, or its enzymatic breakdown in skeletal muscle first-order arterioles.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 69%

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Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

Evanson

Stone

Samraj

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…These results are in agreement with the results of previous studies that used several vasoconstrictors and different time points after OVX, norepinephrine and rats treated 8 days after OVX in the study of Zamorano et al [13] and phenylephrine and rats treated 8 weeks after OVX in that of Crews and Khalil [14]. These results demonstrate that ovarian hormones modulate the contractility that is induced by adrenergic agonists [7,13,15,16]. It is widely accepted that agonist-induced vascular smooth muscle contraction is mediated by Ca 2+ release from intracellular stores and Ca 2+ entry from the extracellular space [17].…”

Section: The Effects Of Ovx On Phenylephrine-and Ca 2+ -Induced Aortisupporting

confidence: 83%

The Effects of 17�-Oestradiol on Increased a₁-Adrenergic Vascular Reactivity Induced by Prolonged Ovarian Hormone Deprivation: The Role of Voltage-Dependent L-type Ca²⁺Channels

Valencia-Hernández

Reyes-Ramírez²,

Urquiza-Marín³

et al. 2012

Pharmacology

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The present study investigated the hypothesis that the duration of ovarian hormone deprivation before reintroduction of oestrogen affects the role of oestrogen as a mediator of the contractile function of α₁-adrenergic receptors. Rats underwent ovariectomy (OVX) or were sham-operated, and the OVX rats were treated with vehicle (corn oil) or 17β-oestradiol (E₂) for 5 days either 10, 28 or 60 days after OVX. The OVX increased phenylephrine- and Ca²⁺-induced contractions. Interestingly, the phenylephrine-induced contractions were increased at each of the three time points, whereas the Ca²⁺-induced contractions were only increased in the 60-day group. E₂ had biphasic effects on phenylephrine- and Ca²⁺-induced contractility. Indeed, E₂ increased contractions in the 10-day group and diminished contractions in the other groups (the increased contractions were avoided by verapamil). These results indicate that E₂ controls α₁-adrenergic receptor-mediated contractility through effects on L-type Ca²⁺ channels in a way that depends on the timing in which the treatment with E₂ is initiated.

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“…Vasoconstrictors like plasma adrenaline and arginine vasopressin have a circadian rhythm; higher in the light [29] and dark [30] phases, respectively. E 2 did not affect these [31,32]. Plasma renin activity and angiotensin related to the synthesis of vasoconstrictor angiotensin II were higher in the light phase in a day [33].…”

Section: Discussionmentioning

confidence: 79%

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

Uchida¹,

Marui²,

Tokizawa³

et al. 2017

Anat Physiol

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The estrus cycle affects the circadian body temperature (T b ) and activity rhythms, and progesterone is related to these alterations. However, it is not clear whether estrogen (E 2 ) influences it. The present study examined whether E 2 affects the circadian T b and activity rhythm. Ovariectomized rats were implanted with a silastic plate with or without E 2 underneath the dorsal skin (E 2 (-) and E 2 (+)), and these along with sham operated rats (SH) were measured for T b and activity for 2 weeks. The mean T b was lower, and mean activity was higher in E 2 (+) than that in E 2 (-) in the day. In the dark phase, the slope of the relationship between the mean T b and activity in E 2 (-) was the greatest. The slope in E 2 (+) and SH was greater in the light phase than that in the dark phase. The daily peak of T b and activity was lower in E 2 (+) than that in E 2 (-). The appearance of the nadir in T b was later in E 2 (+) and SH than that in E 2 (-). The appearance of the peak in T b and activity was earlier in E 2 (+) and SH than that in E 2 (-). Thus, E 2 may modulate the circadian T b and activity rhythm in female rats.

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Rat Carotid Artery Responses to α‐Adrenergic Receptor Agonists and 5‐HT After Ovariectomy and Hormone Replacement

Cited by 10 publications

References 60 publications

Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

The Effects of 17�-Oestradiol on Increased a₁-Adrenergic Vascular Reactivity Induced by Prolonged Ovarian Hormone Deprivation: The Role of Voltage-Dependent L-type Ca²⁺Channels

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

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Rat Carotid Artery Responses to α‐Adrenergic Receptor Agonists and 5‐HT After Ovariectomy and Hormone Replacement

Cited by 10 publications

References 60 publications

Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats

The Effects of 17�-Oestradiol on Increased a1-Adrenergic Vascular Reactivity Induced by Prolonged Ovarian Hormone Deprivation: The Role of Voltage-Dependent L-type Ca2+Channels

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

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The Effects of 17�-Oestradiol on Increased a₁-Adrenergic Vascular Reactivity Induced by Prolonged Ovarian Hormone Deprivation: The Role of Voltage-Dependent L-type Ca²⁺Channels