Rat brain opioid peptides-circadian rhythm is under control of melatonin

Asai, Miguel; Mayagoitia, Lílian; García, David González; Matamoros-Trejo, Gilberto; Valdés-Tovar, Marcela; Leff, Philippe

doi:10.1016/j.npep.2007.09.001

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…In a study involving 26 patients with severe cancer‐related pain, daytime variations in the plasma concentration of active morphine metabolites were observed even with constant dose administration of the drug (Gourlay et al., ). The diurnal variation in opioid receptor expression in rats further underscores a mechanism of circadian variation of BTP (Naber et al., ; Yoshida et al., ; Miguel Asai et al., ).…”

Section: Discussionmentioning

confidence: 99%

Circadian variation of breakthrough pain in cancer patients

Saini

Tucci

Tampellini

et al. 2012

European Journal of Pain

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Section: Discussionmentioning

confidence: 99%

Circadian variation of breakthrough pain in cancer patients

Saini

Tucci

Tampellini

et al. 2012

European Journal of Pain

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“…It was reported that endogenous opioid peptide levels exhibit circadian patterns in the brain, as well as other substances such as the levels of 5-hydroxytryptamine, bradykinin, glutamate, nitrous oxide, substance P, cytokines (IL 1 , IL 6 ) and prostanoids (Asai et al , 2007; Li et al , 2010). These chemical agents are known to be involved in the activation of nociceptors.…”

Section: Discussionmentioning

confidence: 99%

“…Several analgesics are known to exhibit significant circadian rhythm-dependent differences in their pharmacokinetics and dynamics (Asai et al ., 2007; Li et al ., 2010). For example, in humans the duration of analgesia produced by lidocaine is approximately three-fold greater when administered in the late afternoon and early evening than when administered in the morning (Bruguerolle and Labrecque, 2007).…”

Section: Introductionmentioning

confidence: 99%

Morphine administration and abrupt cessation alter the behavioral diurnal activity pattern

Glaser

Reyes-Vázquez

Prieto-Gómez

et al. 2012

Pharmacology Biochemistry and Behavior

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In mammals, there is an underlying mechanism that dictates the organism’s biological functions and daily activity schedule, known as circadian rhythms, which play a major role in maintaining steady metabolism, homeostasis, and immunity. Limited research has been done investigating the effects of continuous opiate administration on the circadian rhythm activity pattern. A change in circadian activity pattern is suggested as an experimental model to demonstrate long-term effect of the drug. The objective of this study was to investigate the effects of morphine treatment on the long term activity (24 hour) of the animal as well as the activity after abrupt removal. Since prescribed medication containing morphine is widely use and abused and its long term effects are not known. Male Sprague-Dawley rats were contained in stable conditions with a standard light/dark cycle recordings were taken before, during and after morphine pellet implantation. Cosinor analysis was used to fit a 24-hour curve to the activity pattern. Results indicate that morphine pellet administration alters the mesor, amplitude, the day-time and night-time activity levels, and during the withdrawal period demonstrates a remarkable change in the maximal circadian rhythm timing. The question whether morphine changes the circadian rhythm or a change in circadian rhythm results in tolerance and withdrawal is discussed.

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“…We previously demonstrated the role of these enzymes in proenkephalin maturation ( 51 , 57 ) and found some of these neuropeptide fragments in temporal lobe epilepsy ( 58 ) and Alzheimer's disease ( 59 ), such as secretogranins for example. Synenkephalin is implicated in circadian rhythm in the hippocampus ( 60 ), Snap25 is implicated in synaptogenesis and memory consolidation ( 61 – 63 ). As previously demonstrated, we confirmed that the somatostatin is present in medulla oblongata ( 64 ) whereas we showed for the first time the presence of the hematological and neurological expressed 1 protein in the hippocampus (fragment) and corpus callosum (full length after methionine excision).…”

Section: Discussionmentioning

confidence: 99%

Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions

Delcourt

Franck

Quanico

et al. 2018

Molecular & Cellular Proteomics

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Tissue spatially-resolved proteomics was performed on 3 brain regions, leading to the characterization of 123 reference proteins. Moreover, 8 alternative proteins from alternative open reading frames (AltORF) were identified. Some proteins display specific post-translational modification profiles or truncation linked to the brain regions and their functions. Systems biology analysis performed on the proteome identified in each region allowed to associate sub-networks with the functional physiology of each brain region. Back correlation of the proteins identified by spatially-resolved proteomics at a given tissue localization with the MALDI MS imaging data, was then performed. As an example, mapping of the distribution of the matrix metallopeptidase 3-cleaved C-terminal fragment of α-synuclein (aa 95–140) identified its specific distribution along the hippocampal dentate gyrus. Taken together, we established the molecular physiome of 3 rat brain regions through reference and hidden proteome characterization.

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Rat brain opioid peptides-circadian rhythm is under control of melatonin

Cited by 13 publications

References 32 publications

Circadian variation of breakthrough pain in cancer patients

Circadian variation of breakthrough pain in cancer patients

Morphine administration and abrupt cessation alter the behavioral diurnal activity pattern

Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions

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