Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway

Askar, Mervat E.; Ali, Sousou I.; Younis, Nahla N.; Shaheen, Mohamed A.; Zaher, Mahmoud E.

doi:10.1016/j.ejphar.2023.176001

Cited by 3 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The researchers found that raspberry ketone treatment significantly reduced intracellular lipid accumulation by inhibiting fatty acid synthesis, promoting fatty acid oxidation, and inhibiting lipogenesis by decreasing the levels of the peroxisome proliferator‐activated receptor γ (PPARγ) mRNA in adipose tissues (Askar et al., 2023 ). These findings suggest that raspberry ketone may contribute to lowering blood cholesterol levels by modulating lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta‐analysis

Jazinaki,

Bahari,

Rashidmayvan

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

Research into the effects of raspberry on blood pressure and lipid profiles is inconclusive. This meta‐analysis was aimed to determine whether raspberry has beneficial effects in clinical practice and to what extent these effects are associated with blood pressure and lipid profiles. A systematic literature search up to September 2023 was completed in PubMed/Medline, Scopus, and Web of Science, to identify eligible RCTs. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were evaluated based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95% confidence interval. Eleven randomized controlled trials (with 13 arms) were eligible for this meta‐analysis. Our findings revealed that Raspberry consumption had no significant effects on the blood pressure and lipid profile markers, including systolic blood pressure (SBP) (WMD, −0.37 mm Hg; 95%CI: −2.19 to 1.44; p = .68), diastolic blood pressure (DBP) (WMD, −2.14 mm Hg; 95%CI: −4.27 to 0.00; p = .05), total cholesterol (TC) (WMD, −6.83 mg/dL; 95%CI: −15.11 to 1.44; p = .10), triglycerides (TG) (WMD, −5.19 mg/dL: 95%CI: −11.76 to 1.37; p = .12), low‐density lipoprotein‐cholesterol (LDL‐C) (WMD, −5.19 mg/dL; 95%CI: −11.58 to 1.18; p = .11), and high‐density lipoprotein‐cholesterol (HDL‐C) (WMD, 0.82 mg/dL; 95%CI: −1.67 to 3.32; p = .51), compared to control groups. Subgroup analysis showed that raspberry consumption significantly decreased total cholesterol and LDL‐C levels in people with elevated TC levels, metabolic syndrome, and andropause symptoms, as well as those older than 35, while the consumption of raspberries led to a significant increase in HDL‐C levels in females, obese, under 35, and healthy individuals. Raspberry can improve lipid profile and blood pressure, but it is important to keep in mind that further research is necessary to fully understand the exact mechanism of action and a definite conclusion in this regard.

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta‐analysis

Jazinaki,

Bahari,

Rashidmayvan

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Polydatin, the glucoside of resveratrol, activates PPARβ signaling pathway to improve lipid metabolism ( 152 ). Raspberry ketone increases phosphorylation of AMPK to improve fatty acid oxidation through upregulation of PPARα and CPT-1 ( 153 ).…”

Section: Natural Compounds In Regulation Of Pparsmentioning

confidence: 99%

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Zhang,

Shi

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. Natural products are structural diversity and have a good safety. Recent studies find that natural herbs and compounds exhibit attractive therapeutic effects on atherosclerosis by alleviating hyperlipidemia and inflammation through modulation of PPARs. Importantly, the preparation of natural products generally causes significantly lower environmental pollution compared to that of synthesized chemical compounds. Therefore, it is interesting to discover novel PPAR modulator and develop alternative strategies for atherosclerosis therapy based on natural herbs and compounds. This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.

show abstract

Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

Li,

Xiao,

Zhao

et al. 2024

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway

Cited by 3 publications

References 58 publications

The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta‐analysis

The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta‐analysis

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

Contact Info

Product

Resources

About