Rasmussen’s encephalitis

Granata, Tiziana; Gobbi, Giuseppe; Spreafico, Roberto; Vigevano, Federico; Capovilla, Giuseppe; Ragona, Francesca; Freri, Elena; Chiapparini, Luisa; Bernasconi, Pia; Giordano, L.; Bertani, Gianna; Casazza, Marina; Bernardina, B. Dalla; Fusco, Lucia

doi:10.1212/wnl.60.3.422

Cited by 125 publications

(105 citation statements)

References 12 publications

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“…The progression of the symptoms to significant neurological impairment usually occurs within months to few years. 17 Although RE causes are unkown, an autoimmune process has been suggested 2,9,12,16 and surgery is the treatment of choice to try to avoid mental retardation, dementia and death. 1 Electroencephalographic usually show a pattern of recurrent seizures, with activity over the central motor area.…”

Section: Introductionmentioning

confidence: 99%

Rasmussen encephalitis: long-term outcome after surgery

et al. 2009

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Background and Purpose: Rasmussen Encephalitis (RE) is characterized by intractable epilepsy, progressive hemiparesis and unilateral hemispheric atrophy. The progression of the symptoms usually occurs within months to few years. Antiepileptic drugs are usually not effective to control disease progression and epilepsy surgery in the form of hemispheric disconnection has been considered the treatment of choice. This work describes the clinical and electrographic analyses, as well as the post-operative evolution of patients with RE. Patients and Methods: This work includes all the patients with RE evaluated from January 1995 to January 2008 by the Ribeirão Preto Epilepsy Surgery Program (CIREP) considering demographic data, interictal and ictal electroencephalographic (EEG) findings; anatomo-pathological findings and clinical outcome. Results: Twenty-five patients were evaluated, thirteen were female. Mean age of epilepsy onset was 4.4±2.0 years. There were no differences between patients with slow and fast evolution with respect to age of epilepsy onset (p=0.79), age at surgery (p=0.24), duration of epilepsy (0.06), and follow-up (p=0.40). There were no correlations between the presence of bilateral EEG abnormalities or the absence of spikes and post-operative seizure outcome (p=0.06). Twenty-three patients underwent surgery. The mean follow-up was 75.3 months. Eleven patients had total seizure control. Twelve individuals persisted with seizures consisting of mild facial jerks (6 patients), occasional hemigeneralized tonic-clonic seizures (3 patients), and frequent tonic-clonic seizures (3 patients). Mental and language impairment was observed in 15 and 12 patients, after surgery, respectively. Conclusions: This retrospective study reported the clinical and electrographic analysis, as well as the evolution of 23 patients with RE. Fourteen patients achieved satisfactory seizure control, three patients had partial response to surgery, and five patients had maintenance of the pre-operative condition. All patients with left side involvement presented with some language and cognitive disturbance.

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Section: Introductionmentioning

confidence: 99%

Rasmussen encephalitis: long-term outcome after surgery

et al. 2009

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“…8 The median age of onset is 6 years, with a range from infancy to adulthood. 8,9,10 In some patients, a prodromal period of mild hemiparesis or infrequent seizures might precede the onset of the acute stage by up to several years. The acute stage is marked by frequent seizures arising from one cerebral hemisphere.…”

Section: Clinical Featuresmentioning

confidence: 99%

Rasmussen's Encephalitis - Chronic Focal Encephalitis (CFE) - A Rare Entity

Kumar¹

2017

jmscr

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Rasmussen's encephalitis, also known as chronic focal encephalitis (CFE), is a rare inflammatory neurological disease, characterized by frequent and severe seizures, loss of motorskills and speech, hemiparesis (paralysis on one side of the body), encephalitis (inflammation of the brain), and CASE REPORTA 12 year old male child presented with history of focal seizures in the form of jerky movements of left upper limb and left lower limb associated with history of up-rolling of eyeball, frothing from mouth and deviation of angel of mouth to right side. There was no associated history of tongue bite, loss of consciousness, altered sensorium, post-ictal confusion, involuntary urination or defecation during episode. These complains were slowly progressive with increasing weakness on left half of body. There was no significant past history and family history related to patients complains.

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“…[30] Etkilenen hemisferde polimorfik delta aktivitesi mevcuttu, başlıca temporal ve santral lokalizasyonluydu, hastaların 9'u aynı zamanda epileptiform anomaliye sahipti. Başlangıçta düzensiz olan temel aktivite hastalık ilerledikçe düzleşme gösterdi.…”

Section: Etiyoloji Ve Patogenezunclassified

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

Kınay¹

2015

Epilepsi

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SummarySome of childhood epileptic syndromes reminds immunological etiologies with their good response to immuno-therapy and histopathological findings. These syndromes, such as Rasmussen encephalitis, FIRES, West syndrome, and Landau-Kleffner syndrome each of which are proceeding with severe epileptic encephalopathy are discussed with their physiopathological, clinical, EEG, laboratory, treatment and prognostic characteristics by the help of current literatüre.

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Rasmussen’s encephalitis

Abstract: The association of partial seizures with focal EEG and neuroimaging changes allows a tentative diagnosis of RE 4 to 6 months after first symptoms.

Cited by 125 publications

References 12 publications

Rasmussen encephalitis: long-term outcome after surgery

Rasmussen encephalitis: long-term outcome after surgery

Rasmussen's Encephalitis - Chronic Focal Encephalitis (CFE) - A Rare Entity

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

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