Rash after a single injection of T‐VEC

Talimogene laherparepvec pseudolymphomatous reaction mimicking metastatic melanoma

“…2,3 It contains granulocyte-macrophage colony-stimulating factor (GM-CSF), which intensifies the response to tumor antigens and indirectly leads to a T-cell response against tumor cells. 3,4 This not only affects the injected tumor itself, but may also lead to the regression of untreated lesions. 5 TVEC is generally used in patients with stage IIIb, IIIc, and IV melanoma.…”

“…2,6,7 Other skin reactions such as pruritus, vitiligo, and erysipelas have also been reported following TVEC therapy. 4 Neutrophilic dermatitis, lymphocytic dermatitis, interface dermatitis, extensive pigment incontinence mimicking melanoma, and panniculitis have also been described. [2][3][4][6][7][8][9][10] In the case of the interstitial lymphocytic dermatitis and panniculitis, the patient's symptoms resolved following the removal of TVEC.…”

“…4 Neutrophilic dermatitis, lymphocytic dermatitis, interface dermatitis, extensive pigment incontinence mimicking melanoma, and panniculitis have also been described. [2][3][4][6][7][8][9][10] In the case of the interstitial lymphocytic dermatitis and panniculitis, the patient's symptoms resolved following the removal of TVEC. 3,4 To the best of our knowledge, pseudolymphomatous reaction in response to TVEC administration has not been previously reported.…”

“…[2][3][4][6][7][8][9][10] In the case of the interstitial lymphocytic dermatitis and panniculitis, the patient's symptoms resolved following the removal of TVEC. 3,4 To the best of our knowledge, pseudolymphomatous reaction in response to TVEC administration has not been previously reported.…”

“…TVEC is a genetically modified herpes simplex virus (HSV)‐1 that selectively replicates and results in tumor lysis 2,3 . It contains granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), which intensifies the response to tumor antigens and indirectly leads to a T‐cell response against tumor cells 3,4 . This not only affects the injected tumor itself, but may also lead to the regression of untreated lesions 5 …”