2015
DOI: 10.1038/npp.2015.228
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Rasd2 Modulates Prefronto-Striatal Phenotypes in Humans and ‘Schizophrenia-Like Behaviors’ in Mice

Abstract: Rasd2 is a thyroid hormone target gene, which encodes for a GTP-binding protein enriched in the striatum where, among other functions, it modulates dopaminergic neurotransmission. Here we report that human RASD2 mRNA is abundant in putamen, but it also occurs in the cerebral cortex, with a distinctive expression pattern that differs from that present in rodents. Consistent with its localization, we found that a genetic variation in RASD2 (rs6518956) affects postmortem prefrontal mRNA expression in healthy huma… Show more

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Cited by 28 publications
(48 citation statements)
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References 51 publications
(77 reference statements)
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“…Notably, we report that the pattern of Rhes mRNA expression in the brain of non-human primates resembles that previously described in humans [8, 12]. Indeed, our observations in adult Macaca Mulatta demonstrate a prominent expression of Rhes transcript in the caudate putamen and, to a lesser extent, in the cortex, with a spatial pattern reminiscent to that in human brain [12].…”
Section: Discussionsupporting
confidence: 80%
See 1 more Smart Citation
“…Notably, we report that the pattern of Rhes mRNA expression in the brain of non-human primates resembles that previously described in humans [8, 12]. Indeed, our observations in adult Macaca Mulatta demonstrate a prominent expression of Rhes transcript in the caudate putamen and, to a lesser extent, in the cortex, with a spatial pattern reminiscent to that in human brain [12].…”
Section: Discussionsupporting
confidence: 80%
“…Indeed, our observations in adult Macaca Mulatta demonstrate a prominent expression of Rhes transcript in the caudate putamen and, to a lesser extent, in the cortex, with a spatial pattern reminiscent to that in human brain [12]. Interestingly, while L-DOPA administration to MPTP-treated monkeys normalized striatal Rhes mRNA levels, this effect was not found in L-DOPA-treated PD patients.…”
Section: Discussionmentioning
confidence: 82%
“…In the present study we documented that Rhes mRNA, beyond its main striatal localization in GABAergic medium spiny neurons, cholinergic large aspiny interneurons, and the hippocampus, is also expressed, although to a lesser extent, in TH‐positive neurons of SNpc and VTA of the mouse midbrain. In addition, we showed that lack of Rhes leads to a mild, although significant, 20% of nigral TH‐positive neuronal loss in both 6‐ and 12‐month‐old mutant animals, when compared with their age‐matched controls.…”
Section: Discussionsupporting
confidence: 52%
“…Single and double in situ hybridization (ISH) analyses were performed according to protocols previously described . Digoxigenin‐( Rhes, TH, Gad67 ) and fluorescein‐conjugated ( TH ) or 35 S‐labeled ( Rhes ) antisense riboprobes were used.…”
Section: Methodsmentioning
confidence: 99%
“…Whether or how RasGRP1 and Rhes signaling participate with this different striatal inputs is currently unknown. Because Rhes and RasGRP1 are also present to some extent in the cortex of the brain (24, 27), their involvement in cortical-striatal signaling is plausible.…”
Section: Discussionmentioning
confidence: 99%