Rasamsonia argillacea mycosis in a dog: first case in Europe

Salgüero, Raquel; Borman, Andrew M.; Herrtage, M. E.; Benchekroun, Ghita; Abbondati, E.; Piola, Valentina; Vanhaesebrouck, An

doi:10.1136/vetreccr.101373rep

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…Similar to other systemic mold infections such as aspergillosis, and in agreement with previous case reports of Rasamsonia infections, discospondylitis with or without vertebral osteomyelitis was a common finding in this cohort of dogs 2,7,11,13 . Dissemination of Rasamsonia is not typical in human patients and accounted for only 30.4% of infected human patients with widespread disease in a recent study, a finding associated with immunosuppression 10 .…”

Section: Discussionsupporting

confidence: 91%

“…Although most dogs underwent rigorous and comprehensive clinical evaluations, the diagnostic evaluation received by dogs was at the discretion of the attending clinician. In addition, reliable conclusions regarding differences in survival time between groups cannot be made, but the survival times of dogs in our study were similar to those of dogs in individual case reports 7,11,13 …”

Section: Discussionsupporting

confidence: 49%

“…Rasamsonia spp. have been described as pathogens of dogs in 4 case reports 7,11‐13 . Three of the 4 dogs were German Shepherd dogs evaluated for multisystemic clinical signs and were euthanized because of progressive disease and declining quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Disseminated Rasamsonia argillacea species complex infections in 8 dogs

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Reagan

Hulsebosch

et al. 2021

Veterinary Internal Medicne

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Background Clinical features, treatment, and outcome of opportunistic infections with Rasamsonia spp., a nonpigmented filamentous mold, are not well documented in dogs. Objectives Describe clinical, radiographic, pathologic features, and outcome of dogs with disseminated Rasamsonia species complex infections. Animals Eight client‐owned dogs. Methods Retrospective case series. Medical records were reviewed to describe signalment, history, clinicopathologic and imaging findings, microbiologic and immunologic results, cyto‐ and histopathologic diagnoses, treatment, and outcome. Results Presenting complaints were nonspecific with anorexia (n = 5) and back pain (n = 4) most common. Five dogs were German Shepherd dogs. Six dogs had multifocal discospondylitis and 2 had pleural effusion. Six dogs had Rasamsonia piperina and 2 had Rasamsonia argillacea infections with isolates identified using DNA sequencing. Rasamsonia spp. were isolated by urine culture in 5 of 7 dogs. Five of 6 dogs had positive serum Aspergillus galactomannan antigen enzyme immunoassay (EIA) results. Median survival time was 82 days, and 317 days for dogs that survived to discharge. Four died during initial hospitalization (median survival, 6 days). All isolates had low minimum effective concentrations (MECs) to echinocandins with variable minimum inhibitory concentrations (MICs) for azole antifungal drugs. Conclusions and Clinical Importance Rasamsonia spp. infections in dogs are associated with multisystemic disease involving the vertebral column, central nervous system, kidneys, spleen, lymph nodes, lungs, and heart. The infection shares clinical features with other systemic mold infections and can be misidentified when using phenotypical microbiologic methods. Molecular techniques are required to identify the organism and guide appropriate antifungal treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 49%

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Disseminated Rasamsonia argillacea species complex infections in 8 dogs

Dear

Reagan

Hulsebosch

et al. 2021

Veterinary Internal Medicne

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“…24,49 R. argillacea has been reported in only 2 dogs to date. 13,38 Other fungi identified in the present series were B. cynodontis, Cladosporium spp., Cryptococcus spp., E. xenobiotica, T. angustata, and an uncharacterized fungus. Among those that have never been described in dogs, B. cynodontis is a dematiaceous hyphomycete widely distributed in soil and normally associated with plant infection.…”

Section: Discussionmentioning

confidence: 97%

Splenitis in 33 Dogs

et al. 2016

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Splenitis is uncommonly reported in dogs. Herein, the authors describe its prevalence, clinical findings and outcomes, histologic patterns, and causes. Splenic samples of dogs diagnosed with splenitis between 2005 and 2013 were collected and stained with hematoxylin and eosin, Gram, green-Gram, Giemsa, periodic acid-Schiff, and Ziehl-Neelsen. Samples were processed for polymerase chain reaction (PCR) to detect bacteria, fungi, and protozoa ( Leishmania infantum, Hepatozoon canis). Thirty-three of 660 splenic samples (5%) had splenitis. Clinical findings and outcomes were available in 19 dogs (58%); 49% had weakness, 33% had fever, and 84% survived. The most frequent inflammatory patterns included purulent splenitis (27%), pyogranulomatous splenitis (24%), and neutrophilic perisplenitis (15%). One dog had a putative diagnosis of primary splenitis; in 8 dogs, microorganisms were identified histologically or by PCR in the spleen without obvious comorbidities. Twenty-four dogs (73%) had concurrent diseases; a permissive role in the development of splenitis was suspected in 21 of these cases. Histologic examination identified the cause of splenitis in 10 dogs. Bacteria were identified by PCR in 23 cases, but the bacteria were confirmed histologically in only 6 of these. Leishmania was detected with PCR in 6 dogs. Leishmania was identified in 1 dog and H. canis in another histologically, but both were PCR negative. Fungi were identified in 8 spleens by PCR and in 1 by histology. This study suggests that splenitis is uncommon in dogs and is frequently associated with systemic diseases. Prognosis is favorable in most cases. Identification of bacteria, fungi, and protozoa in the spleens of affected dogs with PCR should be interpreted cautiously, because the findings are not confirmed histologically in many cases.

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