Ras Signaling in C. Elegans

Eastburn, Dennis J.; Han, Min

doi:10.1007/1-4020-4708-8_9

Cited by 1 publication

(1 citation statement)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…sem-5, soc-1 , and ksr-1 ). 6,7 Sur-8 had been predicted to function downstream of Ras and upstream of Raf and to possess no apparent catalytic activity. 3,4 Subsequent studies suggested that Sur-8/Shoc2 was capable of enhancing ERK1/2 activity by forming a ternary complex with Ras and Raf-1 kinase in response to stimuli from growth factors 8 and showed that Shoc2 can interact with several Ras isoforms.…”

Section: Introductionmentioning

confidence: 99%

The function of Shoc2: A scaffold and beyond

Jang

Galperin

2016

Communicative & Integrative Biology

View full text Add to dashboard Cite

The extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions in multicellular organisms. Scaffold proteins provide critical spatial and temporal control over the specificity of signaling. Shoc2 is a scaffold that accelerates activity of the ERK1/2 pathway. Loss of Shoc2 expression in mice results in embryonic lethality, thus highlighting the essential role of Shoc2 in embryogenesis. In agreement, patients carrying mutated Shoc2 suffer from a wide spectrum of developmental deficiencies. Efforts to understand the mechanisms by which Shoc2 controls ERK1/2 activity revealed the intricate machinery that governs the ability of Shoc2 to transduce signals of the ERK1/2 pathway. Understanding the mechanisms by which Shoc2 contributes to a high degree of specificity of ERK1/2 signaling as well as deciphering the biological functions of Shoc2 in development and human disorders are major unresolved questions.

show abstract

Section: Introductionmentioning

confidence: 99%