Abstract:Introduction: Children with Down syndrome (DS) have a higher incidence of acute lymphoblastic leukemia (ALL) than children without DS. DS-ALL patients have poorer survival than non-DS-ALL patients due to both a high relapse rate and increased treatment-related mortality. DS-ALL is characterized by increased incidence of gene alterations involving CRLF2-JAK pathway. We previously confirmed a high incidence of the P2RY8-CRLF2 fusion (29%) and JAK2 mutations (16%) in Japanese DS-ALL patients, though the frequency… Show more
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