Ras inhibitor farnesylthiosalicylic acid conjugated with IR783 dye exhibits improved tumor-targeting and altered anti-breast cancer mechanisms in mice

Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

“…Previous studies have confirmed that the tumor cell targeting capacity of MHI148 was induced by the high-expressed organic anion transporter polypeptide (OATP) in tumor cells 40 , 41 . Firstly, we evaluated the expression of OTAP-2 and OTAP-8 protein in normal tissue cells and tumor cells ( Supporting Information Fig.…”

Structure-Inherent Tumor-Targeted IR-783 for Near-Infrared Fluorescence-Guided Photothermal Therapy

“…Among the tumor-targeted cyanine dyes commercially available, IR-783 is a representative heptamethine cyanine dye with a good water solubility, owing to its charged structure having two sulfonate groups. Until now, IR-783 has been used continually for tumor imaging in breast, prostate, cervical, and brain cancers in vitro and in vivo, owing to its tumor-selective targeting activity [19][20][21][22]. In particular, IR-783 exhibits a good biocompatibility and less uptake in the reticular and endothelium of the liver or spleen, compared with that of the FDA-approved NIR dye indocyanine green (ICG) showing a high liver uptake [23,24].…”

“…Due to the high tumor uptake but low cytotoxicity of IR-783, Guan et al investigated the anticancer efficacy of the IR-783/genistein conjugate in MCF-7 tumor xenografts of a mice breast cancer model, which displayed improved chemotherapeutic properties compared with the genistein alone [25]. Moreover, Huang et al demonstrated that the IR-783/farnesylthiosalicylic acid conjugate exhibited a superior tumor targetability and anticancer therapeutic efficacy against six human breast cancer cell lines compared with the farnesylthiosalicylic acid alone both in vitro and in vivo [20]. Interestingly, there are no reports of phototherapeutic applications using the IR-783 alone as a single small molecule without the incorporation of nanomaterials.…”

Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment

“…Covalent organic frameworks (COFs) have emerged as a promising platform for drug chemotherapy, photothermal therapy, and photodynamic therapy nanodrug delivery systems for combined treatment due to their regular structures, open one-dimensional channels, tailorable pore spaces, and lipophilicity. − For example, , Chen’s group combined porphyrin COF nanosheets (TP-Por COF) with the near-infrared photosensitizer IR783 and cis -aconitic anhydride-modified doxorubicin to achieve photothermal chemotherapy. Zhang’s group developed a COF system by combining the antifibrosis agent pirfenidone with an imine-linked COF (COFTTA-DHTA) in the combination therapy of photodynamic therapy and drug chemotherapy .…”