Abstract:Glycosylphosphatidylinositol (GPI) anchor biosynthesis is a multi‐step pathway found in all eukaryotes. GPI anchored proteins are involved in a variety of functions like adhesion, host cell attachment, invasion and biofilm formation in Candida albicans, a human pathogenic fungus. The first and committed step of the pathway i.e., transfer of GlcNAc from UDP‐GlcNAc to phosphatidylinositol (PI) to form GlcNAc‐PI, involves an enzyme complex (GPI‐GnT) of six subunits viz. CaGpi1, CaGpi2, CaGpi3, CaGpi15, CaGpi19 an… Show more
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