Rarely seen cardiotoxicity of lithium overdose: Complete heart block

Hospitalized lithium overdose cases reported to theCalifornia Poison Control System

“…Multiple cardiac effects have been reported from lithium toxicity, including nonspecific T-wave changes, 4,5 ST-segment changes, 4,6,7 QTc prolongation, 5,8 sinus node dysfunction, [9][10][11][12][13][14][15][16][17][18][19] AV blocks, [20][21][22] and ventricular dysrhythmias. 23 The exact mechanisms of lithium's cardiac effects are unknown but likely relate to lithium's similarity to sodium and potassium ions.…”

“…[1][2][3] Cardiac toxicity is unusual but has been reported. Documented cardiac effects include nonspecific T-wave changes, 4,5 ST-segment changes, 4,6,7 QTc prolongation, 5,8 sinus node dysfunction, [9][10][11][12][13][14][15][16][17][18][19] AV blocks, [20][21][22] and ventricular dysrhythmias. 23,24 The prevalence of cardiac complications associated with lithium toxicity, however, is not known.…”

Severe Bradycardia Caused by a Single Dose of Lithium

“…Approximately 50% of a single dose of lithium is excreted in 24 hours. The major cardiovascular side effects of lithium include unmasking of Brugada syndrome, sinus node dysfunction, atrio-ventricular (AV) block and various arrhythmias (5,6). Asymptomatic electrocardiographic changes are commonly observed, specifically, changes in T waves characterized by flattening, isoelectrical changes or inversion.…”

QT interval prolongation and bradycardia in lithium-induced nephrogenic diabetes insipidus

“…1, Valeria Materia prepared Figure legend, Antonella Foschi prepared the references [1][2][3][4][5][6][7][8][9][10][11][12][13], Ngambe Mandi Preston prepared the references [14][15][16][17], Chiara Ceriani prepared the references [18][19][20][21][22].…”