Rare virilizing granulosa cell tumor in an adolescent

Bús, Dorottya; Buzogány, Mária; Nagy, Gyöngyi; Vajda, György

doi:10.3892/mco.2016.1084

Cited by 10 publications

(6 citation statements)

References 8 publications

(6 reference statements)

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“…JGCTs is associated with abnormally high estrogen secretion and usually manifest with precocious puberty in about 75% of cases, [5]. Extremely rare examples of virilizing, testosterone-producing JGCT are reported in the literature (2-3% of GCTs) and manifest with hirsutism, amenorrhea, deepening of the voice, clitoral hypertrophy and acne [6]. In contrast, AGCTs usually present with menstrual irregularities, amenorrhea and endometrial hyperplasia [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

Inzani

Santoro

Travaglino

et al. 2021

Arch Gynecol Obstet

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Background Ovarian adult granulosa cell tumours are low-grade malignant sex cord-stromal neoplasm with a low recurrence rate. Prognostic factors for recurrence include tumor stage, tumor rupture in Stage I neoplasms and the presence of residual tumors after surgery. However, in recurrent tumors, prognostic factors for overall survival (OS) are lacking. In the present paper, we conducted a systematic meta-analysis with the aim to assess prognostic factors for OS in patients with recurrent GCT. Methods Electronic databases were searched for all studies assessing prognostic factors in recurrent adult granulosa cell tumor of the ovary. Student T test, Fisher's exact test and Kaplan-Meier survival analysis with long-rank test were used to assess differences among groups; a p value < 0.05 was considered significant. Results Eleven studies analyzing 102 recurrent tumors were included in the systematic review. Tumor stage and localization of recurrent tumors were significantly associated with OS on Kaplan-Meier analysis; Cox regression analysis showed a HR of 0.879 for the stage II, of 3.052 for the stage III, and of 2.734 for stage IV tumor was significantly associated with OS (p = 0.037); observed HRs for abdominal and thoracic locations were of 2.405 and of 4.024, respectively. Conclusions In conclusion, the present article emphasizes the prognostic significance of tumor stage > II and extrapelvic anatomic sites of recurrences in patients with recurrent granuolase cell tumors of the ovary.

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Section: Introductionmentioning

confidence: 99%

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

Inzani

Santoro

Travaglino

et al. 2021

Arch Gynecol Obstet

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“…[ 2 – 5 ] As JGCTs are hormonally active, the majority of patients had some of the typical features such as irregular vaginal bleeding, abdominal distension with pain, breast enlargement, development of pubic and axillary hair, vaginal secretions, and somatoskeletal changes. [ 7 , 8 ] However, the patient in our report did not have such typical symptoms, and her presentation was mainly massive ascites leading to the sudden enlargement of the abdomen. Furthermore, her ascites was gradually absorbed soon after the surgery.…”

Section: Discussionmentioning

confidence: 58%

A rare case report of ovarian juvenile granulosa cell tumor with massive ascites as the first sign, and review of literature

Zhang

Yun

et al. 2018

Medicine

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Rationale:Massive ascites as the first sign of ovarian juvenile granulosa cell tumor (JGCT) in an adolescent is an extremely rare, and its clinical features and treatment methods have not been well described.Patient concerns:The clinical characteristics, diagnosis, and treatment methods in a 19-year-old girl who presented with massive abdominal distention and ascites was retrospectively reviewed. Abdominopelvic ultrasonography showed a large amount of ascites. The nature of ascites was exudate. All tumor markers were normal, but ascites and serum tumor CA125 levels were significantly increased. Abdominal CT showed left attachment area teratoma and right attachment area capsule solid change.Diagnoses:Histological and immunohistochemical results were compatible with JGCT. Based on the FIGO classification, the patient with only malignant ascites was categorized into stage IC.Interventions:The patient underwent mass resection with salpingoophorectomy. Following the operation, she received 6 courses of adjuvant chemotherapy with Nedaplatin and Paclitaxel liposome.Outcomes:The patient was followed up postoperatively for 6 months to date without recurrence.Lessons:We should be highly vigilant the JGCT with massive ascites as the first clinical manifestation.

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“…The presented case of a patient with a granulosa cell tumor is interesting because of the androgen activity of the granulosa cell tumor and the reproductive age of the patient at which this tumor is generally less frequently diagnosed ( Bús et al ., 2017 ). These tumors are most frequently diagnosed after menopause, although they can occur at any age ( Madill et al ., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

Šepić¹,

Severinski²,

Eminović³

et al. 2023

JBRA

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Case Report A 35-yr-old patient suffering from secondary amenorrhea for two years before she was diagnosed. Secondary amenorrhea occurred after the first normal vaginal delivery, and it was initially associated with breastfeeding and a formerly diagnosed thyroid disease. Transvaginal ultrasound confirmed a tumorous mass of the right ovary. Blood hormone tests detected high serum inhibin B and Anti-Müllerian hormone levels and high androgen level with no signs of virilization. Surgical treatment was indicated for a definitive diagnosis of suspected sex cord-stromal tumor. Right-sided laparoscopic salpingo-oophorectomy was performed, and the histopathological analysis confirmed the diagnosis of granulosa cell tumor adult type. The oncological team recommended adjuvant chemotherapy after the operation, but the patient did not give an informed consent. One month after surgical treatment, spontaneous menstrual bleeding occurred with normalization of sex hormone levels and the menstrual cycle. Nine months after surgical treatment, the patient was examined again due to secondary amenorrhea. Ultrasound confirmed a vital intrauterine pregnancy. The pregnancy course was normal, and the patient had a full-term spontaneous vaginal delivery of her second child. Conclusion Restoration of fertility after a temporary loss due to hormone-secreting granulosa cell tumor is possible after sparing surgical treatment. The role of adjuvant chemotherapy is controversial, particularly in patients with stage I-II disease because of the rarity of this tumor and the absence of prospective randomized studies.

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Rare virilizing granulosa cell tumor in an adolescent

Cited by 10 publications

References 8 publications

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

A rare case report of ovarian juvenile granulosa cell tumor with massive ascites as the first sign, and review of literature

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

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