Rare types of breast carcinoma

Gudavičienė, Daiva; Steponavičienė, Laura; Meškauskas, Raimundas; Smailytė, Giedrė; Aleknavičius, Eduardas

doi:10.1515/med-2015-0016

Cited by 6 publications

(5 citation statements)

References 9 publications

(3 reference statements)

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“…The relative rarity of these subtypes is also reported in the South-Eastern [16], North-Eastern and South-Western parts of Nigeria [17,18]. Other parts of West Africa and the rest of the world also reported same pattern [19,20].…”

Section: Introductionmentioning

confidence: 73%

"Squamous Cell Carcinoma of the Breast: A Case Report and Review of Literature"

Aliyu

et al. 2021

BJSTR

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Background: Despite the variety of epithelial malignancies seen in the breast, primary Squamous Cell Carcinoma (SCC) of the breast is rare. It was often classified as one of the metaplastic carcinomas of the breast, although it can arise denovo from benign cysts in the breast. The reported incidence is less than 0.1% of all the ductal carcinomata. It has no distinct clinical features and radiological appearances are also unremarkable. Case Report:We managed a 43-year-old housewife at the General Surgery Unit of University of Maiduguri Teaching Hospital Borno State-Nigeria, who presented with an 11-month old left breast lump that developed malignant features 2 months prior to presentation. A diagnostic Ultra Sound Scan revealed a 10cm retroareola cystic mass with irregular margins and no colour flow on Doppler interrogation, with a provisional diagnosis of a chronic breast abscess. A Fine Needle Aspiration Cytology was equivocal. A wide local excision with axillary dissection was done and postoperative histopathologic analysis showed a primary squamous cell carcinoma. The resection margins were free and only one lymph node showed metastatic deposit. Conclusion:Adenocarcinoma of the breast is the most common malignancy in the breast. The absence of primary squamous cells in the breast renders pure squamous cell carcinoma a rarity. The presentation of squamous cell carcinoma could be similar to that of an adenocarcinoma or bears a benign outlook. It is imperative therefore to subject all benign lesions of the breast to pathological analysis after removal.

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Section: Introductionmentioning

confidence: 73%

"Squamous Cell Carcinoma of the Breast: A Case Report and Review of Literature"

Aliyu

et al. 2021

BJSTR

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“…Being the second most common epithelial type invasive lobular carcinoma (ILC) comprises of 5%-15% of the epithelial tumors [3] . Shakoor et al found that ILC was significantly more likely to spread to distant sites.…”

Section: Discussionmentioning

confidence: 99%

“…Most of breast carcinomas previously termed as "ductal" carcinomas are now categorized as "Invasive ductal carcinoma-no special type," (IDC-NOS) accounting to about 75% to 80%. Following it, the second most common type of breast carcinoma is the Invasive lobular carcinoma, representing about 5% to 15% [3] .…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Special Variants of Breast Carcinoma and Differentiated Ductal Carcinomas with their Immunohistochemistry Profile in a Tertiary Care Centre

Manjula,

Jayanthi,

Srivani

et al. 2024

JMSH

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Background: Breast cancer is a diverse disease with varying characteristics in morphology, presentation, treatment, and prognosis. It constitutes 25% of cancers in Indian women. This study delves into rare special variants and differentiated ductal carcinomas, focusing on their unique histological features and molecular profiles. Aim: To scrutinize the spectrum of special forms of breast carcinoma and their immunohistochemistry (IHC) profile. Material and methods: A retrospective analysis of all the breast carcinomas over a period of 11 months was carried out. The clinical, gross, microscopic and immunohistochemistry findings of 15 special variants and differentiated ductal carcinomas were noted down. Results: In a retrospective analysis of 50 cases of breast carcinoma, 15 were diagnosed as special variants of breast malignancy which accounted to be 30%. Out of the 21 rare histologic subtypes of breast carcinoma 10 variants were encountered by us that included mucinous carcinoma, lobular carcinoma, papillary carcinoma, invasive breast carcinoma with medullary pattern, invasive breast carcinoma with oncocytic pattern, metaplastic carcinoma, cribriform carcinoma, malignant adenomyoepithelioma, secretory carcinoma, and invasive breast carcinoma with neuroendocrine differentiation. Conclusion: This study provides a comprehensive overview of the gross and microscopic features, as well as the immunohistochemistry profiles of these special variants and differentiated ductal carcinomas of the breast. We anticipate that this research will enhance our understanding of these uncommon breast cancer variants, with a particular emphasis on their molecular characteristics, contributing to improved management strategies in the future. Keywords: Breast Cancer, Immunohistochemistry, Molecular Classification

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“…It is estimated that metastasis is responsible for almost 90% of cancer-related deaths [ 5 , 6 , 7 ], a hallmark ability of tumor cells to disseminate to distant organs throughout the body [ 8 , 9 ]. Several other studies have classified more rare subtypes of breast cancer with different behaviors and prognoses which help better define the characteristics and course of the disease [ 3 , 10 , 11 ]. It is worth mentioning that whether the BC is invasive or non-invasive will determine the patient’s treatment strategies and how they may respond to the treatments.…”

Section: Breast Cancer Pathogenesis and Subtypes (Histological And Mo...mentioning

confidence: 99%

Advances of Epigenetic Biomarkers and Epigenome Editing for Early Diagnosis in Breast Cancer

Sarvari

Ramírez-Díaz

et al. 2022

IJMS

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Epigenetic modifications are known to regulate cell phenotype during cancer progression, including breast cancer. Unlike genetic alterations, changes in the epigenome are reversible, thus potentially reversed by epi-drugs. Breast cancer, the most common cause of cancer death worldwide in women, encompasses multiple histopathological and molecular subtypes. Several lines of evidence demonstrated distortion of the epigenetic landscape in breast cancer. Interestingly, mammary cells isolated from breast cancer patients and cultured ex vivo maintained the tumorigenic phenotype and exhibited aberrant epigenetic modifications. Recent studies indicated that the therapeutic efficiency for breast cancer regimens has increased over time, resulting in reduced mortality. Future medical treatment for breast cancer patients, however, will likely depend upon a better understanding of epigenetic modifications. The present review aims to outline different epigenetic mechanisms including DNA methylation, histone modifications, and ncRNAs with their impact on breast cancer, as well as to discuss studies highlighting the central role of epigenetic mechanisms in breast cancer pathogenesis. We propose new research areas that may facilitate locus-specific epigenome editing as breast cancer therapeutics.

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Rare types of breast carcinoma

Cited by 6 publications

References 9 publications

"Squamous Cell Carcinoma of the Breast: A Case Report and Review of Literature"

"Squamous Cell Carcinoma of the Breast: A Case Report and Review of Literature"

Spectrum of Special Variants of Breast Carcinoma and Differentiated Ductal Carcinomas with their Immunohistochemistry Profile in a Tertiary Care Centre

Advances of Epigenetic Biomarkers and Epigenome Editing for Early Diagnosis in Breast Cancer

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