Rare Syringyl Acylated Flavonol Glycosides from the Aerial Parts of Leonurus japonicus Houtt.

Zhang, Yi; Deng, Shumin; Qu, Lu; An, Yonghui; Wu, Chunhua; Han, Lifeng; Gao, Xiumei; Wang, Tao

doi:10.3390/molecules18032967

Cited by 23 publications

(17 citation statements)

References 9 publications

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“…Our results demonstrated that LJE treatment significantly inhibited lipid accumulation and intracellular TG levels in a concentration-dependent manner in FFA-treated HepG2 cells. Consistent with these findings, a previous study stated that leonurusoides from the aerial parts of L. japonicus inhibited TG accumulation in HepG2 cells treated with 0.2 mM oleic acid [ 20 ].…”

Section: Discussionsupporting

confidence: 80%

Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet

2017

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We investigated the effects of a Leonurus japonicus ethanol extract (LJE) on nonalcoholic fatty liver disease (NAFLD). An in vitro model of hepatic steatosis was treated with 1 mM free fatty acid (FFA) in HepG2 cells. An in vivo NAFLD model was established using C57BL/6 mice fed a high-fat diet (HFD) and administered LJE (100 or 200 mg/kg) orally for 14 weeks. LJE treatment suppressed lipid accumulation and intracellular triglyceride levels significantly in a concentration-dependent manner in HepG2 cells. Moreover, LJE significantly reduced the expression of sterol regulatory element binding protein 1-c, and its downstream genes, which are associated with lipogenesis, in HepG2 cells. In HFD-fed mice, LJE treatment decreased body weight significantly and decreased serum alanine transaminase levels to normal values, concurrent with a decrease in hepatic lipid accumulation. Furthermore, LJE supplementation ameliorated insulin sensitivity by decreasing serum glucose and insulin levels. LJE improved hepatic steatosis by increasing the expression of phosphorylated AMP-activated protein kinase and peroxisome proliferator-activated receptor-α in HFD-fed mice and FFA-treated HepG2 cells. The results suggested that LJE might be a potential therapeutic agent to treat NAFLD.

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Section: Discussionsupporting

confidence: 80%

Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet

2017

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“…On the other hand, plasma cholesterol decreased and high density lipoproteincholesterol increased has been reported in L. sibiricus herb extract supplemented feed in mice (Lee et al,2010). Triglyceride (TG) accumulation inhibitory effects has been reported in free fatty acid-induced HepG2 cells due to flavonoids leonurusoides (Zhang et al, 2013) in HW. Our current findings is more or less similar to buckwheat and black cumin supplemented feed .…”

Section: Discussionmentioning

confidence: 99%

Honeyweed (Leonurus sibiricus) and Buckwheat (Fagopyrum esculentum) supplemented diet improve growth performance, lipid profile and hematological values of broiler chicks

Sayed

Abedin

Rahman

et al. 2020

Preprint

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The study was conducted to investigate the combined effects of honeyweed (HW) and buckwheat (BW) supplemented diets on the growth, feed intake, serum lipid profile and blood parameters in broiler chicks. One hundred fifty (150) day old chicks (Cobb-500) were divided into five groups viz. T1 (Commercial control, CC), T2 (FF+10% BW), T3 (FF+10% BW +5% (w/v) HW powder), T4 (FF+10% BW +10% (w/v) HW powder), T5 (FF+10% BW +15% (w/v) HW powder) in complete randomized design with five (5) replications, each of which contain six (6) birds. The CC feed and the FF with HW and BW supplemented diet fed on broiler for 30 days. At the end of the study, the body weight gain, FCR and mortality rate were calculated. It was found that T3 (FF+10% BW +5% (w/v) HW powder) diet significantly (p <0.05) showed the good FCR, mortality rate and body weight gain. Interestingly, T3 decreased the serum cholesterol, triglycerides (TG), low density lipoprotein (LDL), increased high density lipoprotein (HDL) and improves blood parameters significantly (p < 0.05). Our results suggested that this newly formulated feed T3 (FF+10% BW +5% (w/v) HW powder) could be considered as an alternative natural feed additive to hazardous synthetic antibiotics.

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“…The dried herb is used in TCM for the treatment of various diseases, such as menstrual disturbances, dysmenorrhea, and amenorrhea (Liu et al, 2014). Recently, phytochemical studies on this plant have been reported (Romero-González et al, 2006;Ye et al, 2014;Fuchino et al, 2013;Chang et al, 2010;Moon, 2010;Xiong et al, 2013a,b;Zhang et al, 2013;Peng et al, 2013). Our previous investigation on two plants of the family of Lamiaceae resulted in the isolation of a number of new labdane diterpenes (Wu et al, 2011.…”

Section: Introductionmentioning

confidence: 95%

Two new diterpenoids from Leonurus japonicus

Wang

Liu

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tTwo new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a-tetramethyl-3-oxo-3,5,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)furan-2(5H)-one (1), and 5-hydroxy-4-(2-((1R,3S,7aS)-1-hydroxy-4,4,7a-trimethyl-3-propionyloctahydroisobenzofuran-1-yl)ethyl)furan-2(5H)-one (2), were isolated from the EtOH extract of the herb of Leonurus japonicus Houtt., Lamiaceae. Their chemical structures were determined by analysis of 1D, 2D NMR, HRESIMS, and by comparison with known analogs.

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Rare Syringyl Acylated Flavonol Glycosides from the Aerial Parts of Leonurus japonicus Houtt.

Cited by 23 publications

References 9 publications

Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet

Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet

Honeyweed (Leonurus sibiricus) and Buckwheat (Fagopyrum esculentum) supplemented diet improve growth performance, lipid profile and hematological values of broiler chicks

Two new diterpenoids from Leonurus japonicus

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