Rare synchronous metastases of renal cell carcinoma

Rajarubendra, Nieroshan; Pook, David; Frydenberg, Mark; Appu, Sree

doi:10.4103/0974-7796.130652

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…6, № 4 полового члена являются раковые опухоли мочевого пузыря и предстательной железы. Реже встречаются метастазы из опухолей прямой кишки [16][17][18], почки [19] (во всех наблюдениях левой). В качестве казуистической редкости описаны метастатические опухоли полового члена при раке легких, носоглотки, печени, ободочной кишки, желчных путей [20].…”

Section: Introductionunclassified

A Rare Case of Bladder Cancer Metastasis to the Penis

Fedorenko¹,

Udalov²,

Feofilov³

et al. 2022

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Tumors of the penis (both malignant and benign) are fairly rare diseases. Even more rare are cases of metastasis of malignant tumors of other organs to penis. The clinical picture of penile metastatic lesions is highly heterogeneous, ranging from small nodules to massive lesions with or without ulceration, obstructive or irritative symptoms, hematuria or priapism. This article reviews the literature on this rare nosology, as well as from personal experience presents a clinical observation of a rare disease: priapism secondary to bladder cancer metastasis.

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Section: Introductionunclassified

A Rare Case of Bladder Cancer Metastasis to the Penis

Fedorenko¹,

Udalov²,

Feofilov³

et al. 2022

SMV

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Acute scrotal pain and priapism: an early sign of progression in metastatic renal cell carcinoma?

et al. 2015

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SUMMARYA 43 -year-old man was treated with pazopanib for metastatic renal cell carcinoma (RCC) with imaging studies suggesting a partial response to treatment. However, the patient presented numerous times with severe testicular pain and gradually increasing priapism. He underwent an inguinal orchidectomy for symptom control. Histopathology confirmed invasion of the cord and tunica vaginalis with metastatic RCC. Further CT of the abdomen and pelvis suggested non-progression of the disease. The patient continued to develop priapism for several weeks before imaging studies confirmed disease progression; a month later the patient died. Genital involvement in metastatic RCC is unusual but should alert clinicians to the possibility of disease progression. BACKGROUND

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Survival of patients receiving systematic therapy for metachronous or synchronous metastatic renal cell carcinoma: a retrospective analysis

et al. 2019

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Background The differences in progression-free survival (PFS) and cancer-specific survival (CSS) of metastatic renal cell carcinoma (mRCC) patients according to treatment, type of metastasis, and Heng criteria risk are unclear. In this study, we compared survival according to various such parameters. Methods Between 2000 to 2014, 214 mRCC patients, of whom 171 (79.9%) were intermediate-risk and 43 (20.1%) were poor-risk, were retrospectively selected; 126 (58.9%) patients were treated with immunotherapy (IT) and 88 (41.1%) with targeted therapy (TT). Moreover, 144 patients had synchronous mRCCs (67.3%, SM) and 70 had metachronous mRCCs (32.7%, MM). The Kaplan-Meier method and log-rank test were used to compare progression-free survival (PFS) and CSS. Results During a median 4.2 (1.0–70.4) months of systemic treatment and 98.3 (4.8–147.6) months of follow-up, the median PFS and CSS were 4.7 (95% confidence interval [CI]: 3.8–5.5) and 13.8 (95% CI, 9.8–18.3) months, respectively. The PFS and CSS were significantly better in the MM (5.9 and 21.3 months) and intermediate-risk groups (5.2 and 18.3 months) than those in the SM (4.4 and 9.6 months) and poor-risk groups (2.7 and 5.8 months), respectively ( p < 0.05). Further stratification showed that TT produced significantly better PFS than IT in intermediate-risk patients with SM and a treatment-free interval (TFI) < 1 year, and in those with MM with a TFI ≥1 year ( p < 0.05). There were no differences in survival outcomes according to various other subgroup stratifications ( p > 0.05). Conclusion Dividing patients into specific subcategories helps to better predict therapeutic outcomes. Electronic supplementary material The online version of this article (10.1186/s12885-019-5900-1) contains supplementary material, which is available to authorized users.

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Rare synchronous metastases of renal cell carcinoma

Cited by 3 publications

References 9 publications

A Rare Case of Bladder Cancer Metastasis to the Penis

A Rare Case of Bladder Cancer Metastasis to the Penis

Acute scrotal pain and priapism: an early sign of progression in metastatic renal cell carcinoma?

Survival of patients receiving systematic therapy for metachronous or synchronous metastatic renal cell carcinoma: a retrospective analysis

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