Rare Presentation of Pseudotumor Cerebri in a Pediatric Patient With Granulomatosis With Polyangiitis

Sioufi, Henry J; Makvandi, Shayan; Masoud, Rana; Wu, Xiaoyan; Abdul-Aziz, Rabheh

doi:10.7759/cureus.11567

Cited by 2 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found 42 articles with 105 cases: 48 pediatric and 57 adult (71–112), Table 4. The distribution was as follows: hematological diseases (N = 16) (90–93,95–104,106,107), rheumatologic diseases (N = 7): Behçet’s disease and systemic lupus erythematosus (SLE) (71,72,83,94,105,108,109), different genetic diseases (N = 5) (73,74,…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review

et al. 2021

View full text Add to dashboard Cite

Background Idiopathic intracranial hypertension is characterized by increased intracranial pressure without any pathological findings on neuroimaging, except for signs of high intracranial pressure. Before diagnosing idiopathic intracranial hypertension secondary causes of increased intracranial pressure should be excluded. Objective to characterize the phenotype of patients with secondary intracranial hypertension and to identify possible risk factors for secondary intracranial hypertension. Methods We have systematically searched the PubMed database. The publications were analyzed according to the patient phenotype, age, gender, comorbidities, body mass index/weight status, and additional medication. The results are summarized in four categories: medication, infection, hormonal induced intracranial hypertension and miscellaneous groups of diseases related to sIH. Results We identified 105 eligible papers which included 272 cases. There were 49.6% pediatric cases. Among the adult group,70.9% were women. A total of 40.4% of all cases were obese or overweight, 27% among adults and 13.4% among pediatric cases. Increased BMI and recent weight gain, anemia, renal diseases and hypertension were the most frequent comorbidities related to sIH. Conclusion Among sIH patients, 40.4% were obese or overweight; two thirds were women. We recommend that even patients with a typical IIH phenotype should be screened for secondary causes.

show abstract

Section: Resultsmentioning

confidence: 99%

Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Following full work-up and effectively ruling out the infectious cause, the patient in case 3 was diagnosed with pseudo-tumor cerebri (IIH). This is the first documented case of IIH in GPA, and it is unknown whether it is specifically related to the disease process of GPA or treatment of GPA such as the steroid wean or if it is related to another confounding variable altogether [2].…”

Section: Discussionmentioning

confidence: 98%

“…In GPA, anti-neutrophil cytoplasmic antibodies (ANCA) are formed against neutrophilic proteinase-3, thus stimulating a cascade of unregulated inflammation that commonly affects the small-and medium-sized blood vessels of the kidneys and lungs. GPA is the most common AAV overall, with an incidence of 1.2 per 100,000 and on the rise [1][2][3]. Genetics, environment, and variations in both innate and adaptive immunity all play major roles in the pathogenesis of GPA [4,5].…”

Section: Introductionmentioning

confidence: 99%

Renal Involvement and Its Treatment in Pediatric Patients With Proteinase-3 Anti-Neutrophil Cytoplasmic Antibody Positive Granulomatosis With Polyangiitis: A Case Series

Wu¹,

Mancuso²,

Armendi³

et al. 2021

Cureus

Self Cite

View full text Add to dashboard Cite

We describe three pediatric patients between the ages of 10 and 14 years old who were diagnosed with granulomatosis with polyangiitis (GPA) between 2014 and 2019. Each case involves variations in presentation, symptomatology, diagnostics, and induction and maintenance therapy regimens. Patient 1 presented with significant renal involvement, hypertensive emergency, and focal alveolar hemorrhage, a rare presentation of GPA that causes up to 60% mortality. Patient 2 presented with minimal renal involvement and a diffuse petechial rash, which is the most common cutaneous presentation of GPA. Finally, patient 3 presented with significant renal involvement and later on with symptoms of idiopathic intracranial hypertension (IIH), a unique and rare presentation associated with GPA. Despite the heterogeneity of these cases, the similar therapy regimens used in each case successfully achieved induction and maintenance of disease remission, providing an evidentiary basis for these treatment regimens even in severe and unusual pediatric GPA cases.

show abstract

Rare Presentation of Pseudotumor Cerebri in a Pediatric Patient With Granulomatosis With Polyangiitis

Cited by 2 publications

References 8 publications

Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review

Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review

Renal Involvement and Its Treatment in Pediatric Patients With Proteinase-3 Anti-Neutrophil Cytoplasmic Antibody Positive Granulomatosis With Polyangiitis: A Case Series

Contact Info

Product

Resources

About