“…This indicates the absence of rearrangement hotspots, which is in line with previous findings (Beysen, et al, 2005;D'haene, et al, 2009;Shaw and Lupski, 2004). These nonrecurrent rearrangement events are suggestive of nonhomologous end joining (NHEJ), alternative NHEJ (alt-NHEJ), or Fork Stalling and Template Switching (FoSTeS) as possible underlying mechanisms (Lee, et al, 2007;Shaw and Lupski, 2004;Vissers, et al, 2009). Noteworthy, we recently proposed a mechanism that triggered the generation of a deletion upstream of FOXL2 in a patient with BPES (D 'haene, et al, 2009).…”