Rare mediastinal leiomyoma in a child

Hakeem, Zubair Ashraf; Rathore, Shyam Singh; Wahid, Abdul

doi:10.1007/s11748-016-0705-5

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Patients with mediastinal leiomyoma are typically 22-to 67-year-old adults, although children can also be affected in rare cases. 153 There is a strong female predominance, with a female-to-male ratio of 5:1. Most cases arise in the posterior mediastinum, followed by the middle and anterior compartments.…”

Section: Leiomyomamentioning

confidence: 99%

“…Mediastinal leiomyoma accounts for < 6% of all primary mediastinal mesenchymal neoplasms149–152 and sometimes arises from vascular trunks. Patients with mediastinal leiomyoma are typically 22- to 67-year-old adults, although children can also be affected in rare cases 153. There is a strong female predominance, with a female-to-male ratio of 5:1.…”

Section: So-called Fibrohistiocytic Tumorsmentioning

confidence: 99%

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Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Choi¹,

Ro²

2021

Advances in Anatomic Pathology

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Mesenchymal tumors of the mediastinum are a heterogenous group of rare tumors with divergent lineages. Mediastinal mesenchymal tumors are diagnostically challenging due to their diversity and morphologic overlap with nonmesenchymal lesions arising in the mediastinum. Accurate histologic diagnosis is critical for appropriate patient management and prognostication. Many mediastinal mesenchymal tumors affect distinct age groups or occur at specific mediastinal compartments. Neurogenic tumors, liposarcoma, solitary fibrous tumor, and synovial sarcoma are common mesenchymal tumors in the mediastinum. Herein, we provide an update on the diagnostic approach to mediastinal mesenchymal tumors and a review of the histologic features and differential diagnosis of common benign and malignant mesenchymal tumors of the mediastinum.

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Section: Leiomyomamentioning

confidence: 99%

Section: So-called Fibrohistiocytic Tumorsmentioning

confidence: 99%

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Choi¹,

Ro²

2021

Advances in Anatomic Pathology

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“…Bili su to prikazi jednog slučaja ili male serije slučajeva 10,14-21 . Najčešće se javljaju u odrasloj dobi, ali opisan je i slučaj LM-a medijastinuma dječaka u dobi od jedne i pol godine 21 . LMS-i čine manje od 2 % svih malignih tumora medijastinuma 18 .…”

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Mediastinal smooth muscle tumor of uncertain malignant potential: case report and literature review

Flego¹,

Volarić

Matušan-Ilijaš

et al. 2019

Med flum

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Sažetak. Cilj: glatkomišićni tumori su lejomiomi i lejomiosarkomi. Postoji rijetka skupina, u kojoj se biološki potencijal tumora ne može utvrditi; to su glatkomišićni tumori nepoznatog malignog potencijala. Cilj je prikazati pacijenta s takvim tumorom, koji je nastao iz glatkog mišićnog tkiva medijastinuma. Prikaz slučaja: 48-godišnji muškarac, subfebrilan, bolovi u grudnom košu sa širenjem u leđa. Kompjutorizirana tomografija toraksa pokazala je oštro ograničenu cističnu tvorbu stražnjeg medijastinuma. Ezofagogastroduodenoskopija je otkrila u srednjoj trećini jednjaka pritisak izvana, a rendgen pasaža jednjaka jednjak lučno potisnut izvana prema desno i ventralno. Bronhoskopijom je utvrđeno da je membranozni dio lijevog glavnog bronha blago ekstramuralno komprimiran. Učinjen je kirurški zahvat, torakotomija lijevo i potpuno odstranjenje tumora medijastinuma. Patohistološki nalaz pokazao je područje nekroze, tumorsko tkivo građeno od vretenastih stanica, koje pokazuju blagu polimorfiju. Imunohistokemijska analiza tumora bila je pozitivna na glatkomišićni aktin (SMA) i dezmin, a negativna na S100 i CD34, što potvrđuje podrijetlo tumora iz glatkomišićnih stanica. Dodatna imunohistokemijska analiza utvrdila je da proliferacijski biljeg Ki-67 iznosi 5,9 %, a p16 je pozitivan u više od 50 % tumorskih stanica. Zaključni patološki nalaz je glatkomišićni tumor nepoznatog malignog potencijala. Pacijent je praćen 48 mjeseci nakon operacije, bez recidiva tumora ili znakova metastaza. Zaključak: Patohistološka dijagnoza može biti otežana, općenito, ali posebno u rijetkim novotvorevinama. Prikazani slučaj pokazuje da ponekad nije moguće utvrditi radi li se o benignom ili malignom glatkomišićnom tumoru. Tada se postavlja dijagnoza glatkomišićnog tumora nepoznatog malignog potencijala, ovdje smještenog u medijastinumu. Nakon kirurškog odstranjenja neoplazme potrebno je redovito pratiti pacijenta, kako bi se utvrdio recidiv bolesti i provelo dodatno liječenje. Abstract. Aim: Smooth muscle tumors are divided into leiomyomas and leiomyosarcomas.The aim is to present a patient with a rare tumor called smooth muscle tumor of uncertain malignant potential. Case report: The reported patient was a 48-year-old male, subfebrile, with chest pain. Chest computed tomography showed a sharply limited cystic formation of the posterior mediastinum. Esophagogastroduodenoscopy revealed outside compression in the middle third of the esophagus, and X-ray of the esophageal passage showed that the esophagus was pressed from the outside to the right and ventral. Bronchoscopy determined that the membranous part of the left main bronchus was slightly extramurally compressed. A left thoracotomy and an extirpation of the mediastinal tumor were performed. In pathohistology area of necrosis and tumor tissue composed of spindle cells were identified, which showed mild polymorphia. Immunohistochemical findings included positive smooth muscle actin (SMA) and desmin markers, negative S100 and CD34 markers, Ki-67 was 5.9%, and p16 was positive in more than 50% ...

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Mesenchymal Tumors of the Mediastinum

Weissferdt

2020

Diagnostic Thoracic Pathology

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Rare mediastinal leiomyoma in a child

Cited by 4 publications

References 4 publications

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Mediastinal smooth muscle tumor of uncertain malignant potential: case report and literature review

Mesenchymal Tumors of the Mediastinum

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