Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders
Gerda E. Breitwieser,
Andrea Cippitelli,
Yingcai Wang
et al.
Abstract:GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since its role in humans is not fully defined, we used an unbiased computational approach to assess the clinical significance of rare GPR37L1 genetic variants found among 51,289 whole-exome sequences from the DiscovEHR cohort. Briefly, rare GPR37L1 coding variants were binned according to predicted pathogenicity, and then analyzed by Sequence Kernel Association testing to reveal significant associa… Show more
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