Rare Extraintestinal Manifestations of Inflammatory Bowel Disease

Hoffmann, Robert M.; Kruis, Wolfgang

doi:10.1097/00054725-200403000-00013

Cited by 60 publications

(42 citation statements)

References 118 publications

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“…Although abnormalities in large airways (e.g. bronchiectasis) are prevalent in these diseases, bronchiolitis has also been described [85,86]. When present, respiratory manifestations usually occur in patients already diagnosed with inflammatory bowel disease, sometimes after colectomy [87].…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

European Respiratory Review

104

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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

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Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

European Respiratory Review

104

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“…The involvement of the lungs in systemic autoimmune diseases is common and ranges from ∼5% in rheumatoid arthritis or systemic lupus erythematosus [63], to 40-60% in inflammatory bowel disease [64], and up to 90% in anti-neutrophil cytoplasmic antibodies-associated vasculitides [65]. Despite the strong association of connective tissue disease with ILDs, information on the involvement of small airways (bronchiolitis) is limited.…”

Section: Autoimmune Airway Diseasementioning

confidence: 99%

Should lung biopsies be performed in patients with severe asthma?

2015

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Asthma, and severe asthma, in particular, is increasingly recognised as a heterogeneous disease. Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) better understanding or identifying the diagnosis, and 2) providing information on the heterogeneity of asthma phenotypes to guide therapy with the objective of improving outcomes. Lung biopsies can target the large and small airways as well as the lung parenchyma. All compartments are affected in severe asthma; however, knowledge on the distal lung is limited. At this point, it remains uncertain whether lung specimens routinely add diagnostic information that is unable to be obtained otherwise. Indeed, whether a lung biopsy is indicated in the workup of a patient with severe asthma remains an individual decision. It is hoped this review will support rational decision-making and provide a detailed synopsis of the varied histopathological features seen in biopsies of patients with a diagnosis of severe asthma. Due to limited data on this topic this review is primarily based on opinion with recommendations arising primarily from the personal experience of the authors.

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“…An association between UC and multiple sclerosis (MS) has been found both within families and within individuals (Hoffmann & Kruis, 2004). MS affects UC more than CD patients and the prevalence of MS in IBD patients is about 3.7 times more than seen in the average (Kimura et al, 2000).…”

Section: Immune Mediated Neuropathymentioning

confidence: 99%