Abstract:PURPOSE: To evaluate associations between rare dysfunctional Complement Factor I (CFI) genetic variant status and progression to advanced age-related macular degeneration (AAMD), geographic atrophy (GA) and neovascular disease (NV). DESIGN: Prospective, longitudinal study PARTICIPANTS: Patients aged 55-80 years at baseline identifying as white with non-advanced AMD in one or both eyes at baseline were included. Follow-up grades were assigned as early, intermediate, or AAMD (GA or NV). CFI variants were categor… Show more
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