Rare Diseases with Periodontal Manifestations

Hanisch, Marcel; Hoffmann, Thomas; Bohner, Lauren; Hanisch, Lale; Benz, Karin; Kleinheinz, Johannes; Jackowski, Jochen

doi:10.3390/ijerph16050867

Cited by 24 publications

(18 citation statements)

References 92 publications

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“…There are numerous correlations between problems or oral alterations and systemic health of the patient [1][2][3][4][5]. In particular, the implications of chronic oral inflammation, such as periodontitis, may be different [6]. Having both an influence on the course of oral and general conditions.…”

Section: Rationalementioning

confidence: 99%

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

et al. 2019

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In recent scientific literature, oral infections and systemic manifestations, or correlations between oral health and systemic diseases are a topic of discussion. Porphyromonas gingivalis is one of the bacteria implicated in the biofilm formation of bacterial plaque, and plays an important role in the progression of periodontal disease. In this systematic review authors have evaluated the literature of the last 10 years on P. gingivalis and all the systemic implications proven. This study therefore evaluates all the districts of the organism in which this bacterium may have implications. From the results it emerges that P. gingivalis has implications in the onset of different systemic pathologies, including rheumatoid arthritis, cardiovascular pathologies, and neurodegenerative pathologies. Surely, understanding the mechanisms of diffusion of this bacterium, it would be possible to prevent a series of pathologies. Thus, putting the dentist clinician at the center of prevention for these diseases.

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Section: Rationalementioning

confidence: 99%

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

et al. 2019

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“…More than two-thirds of the respondents described oral symptoms. Especially in rare diseases, the oral symptoms, such as those described in EDS, [4,5,6,7,8,9,10,11] may provide an important indication of the underlying disease. Dentists who correctly identify oral symptoms can significantly contribute to earlier diagnosis of the underlying disease.…”

Section: Discussionmentioning

confidence: 99%

“…[3] In the case of EDS, the prevalence varies, depending on the type: between 1:30,000 (classical type) and < 1:1,000,000 (arthrochalasia type), whereas for the rarest form (the periodontitis type), the prevalence is unknown. [1] EDS' oral symptoms have been described as periodontitis, [2,4,5] temporomandibular dysfunctions, [2,6] bleeding tendencies, [7,8] enamel hypoplasia, [2,9] shape abnormalities of the teeth and changes in the number of teeth, [2,8] a high palate, [2,10] dysgnathia, and malocclusion, [2,11] as well as decreased effects of local anaesthesia. [12,13] To date, there have been only a few studies on the oral health-related quality of life (OHRQoL) of people with EDS who report reduced OHRQoL.…”

Section: Introductionmentioning

confidence: 99%

Oral symptoms and oral health related quality of life in people with Ehlers-Danlos syndromes (EDS): a questionnaire-based cross-sectional study

Hanisch

Blanck-Lubarsch

Maus

et al. 2020

Preprint

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Background: To date, there have only been a few studies on the oral health-related quality of life (OHRQoL) of people with Ehlers-Danlos syndromes (EDS) and the oral symptoms. The aim of this study was, therefore, to analyse the OHRQoL of people with EDS from their own point of view as well as obtain information about their age at the time of the diagnosis, the period of time until diagnosis, and the presence of oral symptoms (if any) and their association with oral health quality.Methods:The study was designed as an anonymous questionnaire-based cross-sectional study. We conducted a descriptive analysis of the Oral Health Impact Profile-14 (OHIP-14) scores, age of the participants, age at diagnosis, and the time period between the first signs of the disease and the diagnosis of EDS. To verify the differences in OHIP-14 scores between patients with and without oral symptoms, a Mann-Whitney U test was performed.A multivariate quantile (median) regression analysis was performed to evaluate the effect of different general characteristics (gender, age, and the presence of oral symptoms) on the OHIP‑14 scores. Furthermore, using a Mann-Whitney U test, the influence of different oral symptoms was verified by testing the differences between patients without any oral symptoms and patients with a specific diagnosis.Results:A total of 79 evaluable questionnaires from 66 female (83.5%) and 13 male (16.5%) participants were analysed. On average, after the first symptom, it takes 18.36 years before EDS are correctly diagnosed.Oral symptoms were described by 69.6% of the participants. The OHIP-14 score was 8 (10) points for patients without oral symptoms and 19 (15) for patients with oral symptoms. The quantile regression for OHIP-14 scores, depending on oral symptoms, was highly significant (p = 0.0007). OHIP-14 scores for dysgnathia, periodontitis, TMD, a high-arched palate, malocclusion, and the anomaly of tooth formation were significantly different between the participants with and the participants without oral symptoms.Conclusion:Long diagnostic pathways seem to be a typical problem in patients with EDS. Oral symptoms associated with the underlying disease occurred regularly and showed a negative correlation with OHRQoL.

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“…In this report, we present a rare case of localized periodontal destruction between teeth 25 and 26, which was ultimately diagnosed as an actinomycosis (or Actinomyces-associated lesion) based on histopathology, although the clinical presentation resembled a simple localized severe periodontitis. It is noteworthy that approximately 14 percent of rare diseases with orofacial involvement also show manifestations in the form of gingivitis, periodontitis, and gingival hyperplasia in connection with the underlying disease [15]. However, the new classification of periodontal and peri-implant diseases and conditions does not consistently mention or classify them.…”

Section: Introductionmentioning

confidence: 99%

Actinomycosis as a Rare Local Manifestation of Severe Periodontitis

Kaldas

Barghorn²,

Schmidlin

2020

Case Reports in Dentistry

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Actinomycosis is a chronic suppurative infection primarily caused by anaerobic gram-positive filamentous bacteria, primarily of the genus Actinomyces. Oral-cervicofacial actinomycosis is the localization found most often, presenting as a soft tissue swelling, an abscess, a mass lesion, or sometimes an ulcerative lesion. Periodontitis-like lesions, however, are rare findings. This report describes the case of a 41-year-old healthy female patient (nonsmoker), who was referred to the clinic with dull and throbbing pain in the second quadrant. Tooth 25 showed increased mobility and probing pocket depths up to 10 mm, with profuse bleeding upon probing. Radiographically, considerable interproximal horizontal bone loss was found, and the diagnosis of periodontitis stage 3, grade C was made. The situation was initially stabilized with adhesive splinting and local anti-infective therapy. Two weeks later, the bone defect was treated with guided tissue regeneration (GTR) using a xenogenic filler material (BioOss Collagen) and a resorbable membrane (Bio-Gide). Due to a suspicious appearance of the excised granulation tissue, the collected fragments were sent for histopathological evaluation. This evaluation revealed a chronic granulomatous inflammation with the presence of filamentous bacterial colonies, consistent with Actinomyces. The patient was successfully treated. While there are only few reports in the literature, actinomycotic lesions represent a rare but possible finding in cases with localized periodontal destruction. In conclusion, systematic biopsy of the infrabony tissue in localized periodontal lesions may help to provide a more accurate counting of Actinomyces-associated lesions, thereby improving diagnosis, therapy, and prevention.

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Rare Diseases with Periodontal Manifestations

Cited by 24 publications

References 92 publications

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

Oral symptoms and oral health related quality of life in people with Ehlers-Danlos syndromes (EDS): a questionnaire-based cross-sectional study

Actinomycosis as a Rare Local Manifestation of Severe Periodontitis

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