Rare diseases bullet 8: Organising pneumonia

Cordier, Jean-François

doi:10.1136/thorax.55.4.318

Cited by 277 publications

(119 citation statements)

References 181 publications

(70 reference statements)

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“…The pathogenesis of organizing pneumonia is that of an inflammatory lung disease, rather than of a fibrosing process, such as that seen in interstitial pneumonia [2, 3]. Thus, the majority of patients with organizing pneumonia generally respond to steroid therapy [1].…”

Section: Discussionmentioning

confidence: 99%

Organizing pneumonia associated with M ycobacterium tuberculosis infection

Yoon

Lee

Chon

et al. 2015

Respirology Case Reports

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Organizing pneumonia is an inflammatory lung disease involving the distal bronchioles, respiratory bronchioles, bronchiolar ducts, and alveoli. A number of viral and bacterial organisms have been identified as causative agents of organizing pneumonia. However, M ycobacterium tuberculosis has rarely been reported as a causative agent. Herein, we report our experience with two patients diagnosed with pulmonary tuberculosis, whose biopsies showed patterns associated with organizing pneumonia. Both patients showed positive results for bacteriological tests and presence of acid fast bacilli. Hence, we could successfully treat both patients with anti‐tuberculosis medications. Our report suggests that M . tuberculosis infection could be added to the list of infectious conditions associated with organizing pneumonia.

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Section: Discussionmentioning

confidence: 99%

Organizing pneumonia associated with M ycobacterium tuberculosis infection

Yoon

Lee

Chon

et al. 2015

Respirology Case Reports

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“…BOOP may be classified into three categories according to its etiology: organizing pneumonia of determined cause; organizing pneumonia of undetermined cause but occurring in a specific and relevant context, and cryptogenic (idiopathic) organizing pneumonia [4]. The first two groups were classified as secondary BOOP in our series.…”

Section: Discussionmentioning

confidence: 99%

“…Its full clinical spectrum and course are variable. With steroid therapy, BOOP has a good prognosis [1, 2, 3, 4]. However, some patients may relapse when the glucocorticoid dose is reduced [2, 6], and some cases may progress rapidly and have a poor prognosis [7].…”

Section: Introductionmentioning

confidence: 99%

“…BOOP is characterized by subacute illness with shortness of breath, fever, malaise, and weight loss present for a period ranging from 3 to 6 months [1, 3, 4]. Its full clinical spectrum and course are variable.…”

Section: Introductionmentioning

confidence: 99%

“…These histologic features are a common pattern of repair. BOOP may be secondary to a number of clinical settings including inhalation of toxic fumes, immunologic and connective tissue disorders, reaction to viral, bacterial, or fungal infections; inflammatory bowel disease, human immunodeficiency virus infection, common variable immune deficiency (CVID), radiation therapy, myelodysplastic syndrome, drug reactions, malignant diseases, and bone marrow or solid organ transplantation [1, 2, 3, 4, 5]. The disease in other patients is idiopathic, and idiopathic BOOP has been named ‘cryptogenic organizing pneumonia’ [1, 2, 3, 4].…”

Section: Introductionmentioning

confidence: 99%

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Bronchiolitis obliterans Organizing Pneumonia

Oymak

Demirbaş

Mavili³

et al. 2005

Respiration

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Background: Bronchiolitis obliterans organizing pneumonia (BOOP) may be classified as cryptogenic (idiopathic) and secondary. There are no clear clinical and radiological features distinguishing between idiopathic and secondary BOOP. Objectives: To analyze the etiologic factors, clinical and radiological features, diagnostic approach and response to therapy at onset and outcome in subjects with BOOP. Methods: The medical files of Erciyes University Hospital from 1995 to 2003 were retrospectively reviewed. Patients with biopsy-proven BOOP were selected for evaluation. The etiology and initial features of BOOP, treatment, resolution, relapse, and survival were obtained from medical records, and a follow-up patient questionnaire. Results: We have diagnosed 26 cases (13 males /13 females) with BOOP syndrome (mean age 54 ± 15 years, range 14–93). More than half the patients (58%) were classified as idiopathic BOOP. Patients presented with cough (92%), dyspnea (70%), pleuritic chest pain, hemoptysis and fever (50%). The biopsy specimens had been obtained by transbronchial and/or transthoracic lung biopsy in 18 cases (69%). At radiological evaluation, there were bilateral patchy alveolar and/or interstitial infiltrates in 16 patients (62%), and solitary pneumonic involvement in 10 patients (38%). Three patients recovered spontaneously, 5 remained cured after resection of the focal lesion. Corticosteroid therapy was given in 17 patients (65%). Apart from four patients who died (death was attributable to BOOP in only 1 patient) and three patients who relapsed, the prognosis was good in all patients. Conclusions: The etiology of BOOP is usually idiopathic. We observed that hemoptysis and pleuritic chest pain were a relatively frequent symptom in BOOP in the present series, in contrast to previous observations. The diversity of radiological and clinical presentations including hemotysis and pleuritic chest pain should prompt consideration of the diagnosis in patients with persisting pulmonary symptoms and radiological findings.

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