Rare causes of cryptogenic stroke

Abstract

Stroke is one of the leading causes of mortality and disability in the world, which is why it is considered a key medical and social problem of modern medicine. According to international multicenter studies, ischemic stroke is the most frequent type of this condition. According to research, the pathogenetic subtype of ischemic stroke cannot be identified in a third of cases. Based on the TOAST classification, cryptogenic stroke requires exclusion of criteria for other pathogenetic subtypes. However, in clinical practice, the reasons for making this diagnosis are as follows: incomplete examination of the patient, negative test results, and identification of two or more causes. The high incidence and risk of recurrent ischemic events determines the need for a thorough diagnostic search in order to exclude rare causes and conduct reasonable secondary prophylaxis.