Rare cause of pulmonary cavitation in a 75-year-old man

Al-Sheikhli, Jaffar; Taqi, Hussein; Drake, John M.; Habib, Ayaaz

doi:10.1136/bcr-2017-222792

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…In a larger data of retrospective analysis, fever and hemoptysis were the important characteristics of PM (2). There are still other complaints, such as shortness of breath (20,21), chest wall tenderness (22), chronic dyspnea (23) and so on.…”

Section: Discussionmentioning

confidence: 97%

Characteristics of pulmonary mucormycosis and the experiences of surgical resection

Shao¹,

Zhang²,

Ma³

et al. 2020

J Thorac Dis

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Background: Pulmonary mucormycosis (PM) is a relatively rare but fatal infection. However, detailed surgery data have been lacking. We summarized the characteristics of this rare disease and clarified the experiences of surgical resection Methods: We conducted a single-center retrospective study of seven patients with PM who underwent surgical resection at China-Japan Friendship Hospital from May 2011 to May 2018. Results: Patient ages ranged from 18 to 70 years, with a median age of 47 years. Manual workers (85.7%) were the most common occupation and their educational level was also below high school. Diabetes was the most common underlying condition. The most common radiographic finding was lobar consolidation.Three patients directly underwent open thoracotomy, one patient underwent video-assisted thoracic surgery (VATS) and three patients converted from VATS to thoracotomy. The median operation time was 240 min [interquartile range (IQR), 150-390 min], the median intraoperative blood loss was 500 mL (IQR, 100-1,200 mL) and the median intraoperative blood transfusion was 600 mL (IQR, 0-1,600 mL). In-hospital, 90-day, 1-year and 5-year mortality were 14.3%, 14.3%, 28.8% and 42.9%, respectively. Conclusions: PM is a rare but fatal infection. Due to chest adhesion and vascular invasion, the proportion of massive bleeding and long operation time has increased sharply.

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Section: Discussionmentioning

confidence: 97%

Characteristics of pulmonary mucormycosis and the experiences of surgical resection

Shao¹,

Zhang²,

Ma³

et al. 2020

J Thorac Dis

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“…To date, only 17 cases of R. microsporus involving lungs as site of infection (pulmonary mucormycosis) has been reported in the literature and are listed in Table I. [3][4][5]11,[15][16][17][18][19][20] The patients included 12 males and 5 females with the average age of 62 (28-88) years. 5 cases were reported from India, 4 from Belgium, 2 from United States and one case each from United Kingdom, Kenya, Japan, Czechia, The Netherlands and South Korea.…”

Section: Discussionmentioning

confidence: 99%

Rhizopus microsporus pulmonary sepsis: Case report and review of literature

Umamaheswari

Gnanasekar²,

Kumar³

2022

IJMMTD

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The incidence of opportunistic fungal infection, mucormycosis associated with high mortality rate is steadily increasing. Pulmonary mucormycosis though rare, it relatively affects individuals with diabetes mellitus and other immunosuppressive conditions. The present study reports on case of pulmonary mucormycosis caused by Rhizopus microsporus. Sputum sample was collected from a 47-year-old male with diagnosed with tuberculosis with spontaneous left sided pneumothorax and diabetes mellitus. The positive fungal culture was characterized by phenotypic and genotypic methods and antifungal susceptibility of the isolate was tested against azoles and amphotericin B. The etiological agent was identified as R. microsporus based on phenotypic features and molecular sequencing of ITS. The isolate was susceptible to all the tested antifungal and the patient responded well to Amphotericin B with strict glycemic control and combination of anti-infective therapy. Though pulmonary mucormycosis is relatively rare; it share its clinical picture with pulmonary tuberculosis and aspergillosis, hence clinical suspicion for mucormycosis in susceptible high risk patients is warranted for early diagnosis and appropriate therapy.

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“…However, among patients who received combined surgical and pharmacologic treatment, survival increased to 70% [3]. Among patients undergoing therapy for hematologic malignancies or transplantation, mortality is particularly high (52–91%) [8], [9].…”

Section: Discussionmentioning

confidence: 99%

Breaking the mold: A case of pulmonary mucormycosis treated with isavuconazole

Huggins

Jurdi

Gupta

2019

Medical Mycology Case Reports

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Pulmonary mucormycosis is a rare opportunistic invasive fungal infection that disproportionately affects immunocompromised hosts and carries high morbidity and mortality. It is traditionally treated with combined pharmacologic and surgical modalities. Here we present a case of pulmonary mucormycosis in a patient whose disease burden precluded surgical management, and in whom acute kidney injury necessitated therapy with an alternative to the recommended pharmacologic antifungal therapy.

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Rare cause of pulmonary cavitation in a 75-year-old man

Cited by 3 publications

References 14 publications

Characteristics of pulmonary mucormycosis and the experiences of surgical resection

Characteristics of pulmonary mucormycosis and the experiences of surgical resection

Rhizopus microsporus pulmonary sepsis: Case report and review of literature

Breaking the mold: A case of pulmonary mucormycosis treated with isavuconazole

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