Rare Case Report: Young Male Hard Palate Pleomorphic Adenoma

Gupta, Pankaj; Gupta, Moulik

doi:10.1007/s12070-020-01887-w

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Clinically, the RPA on the palate were small, firm, and smooth nodules, asymptomatic, often covered by normal oral mucosa, and measuring up to 3 cm in diameter 21 , 22 , 28 - 33 , confirming the pattern well-established of the slow growing for this tumor in this location 3 , 37 , 38 . Imaging examinations consistently showed a hypodense maxillary lesion, often with well-defined borders, extending into the maxillary sinus, nasal cavity, and orbital cavity.…”

Section: Discussionsupporting

confidence: 65%

“…The RPA on the palate can lead to malignant transformation, negatively impacting the patient’s prognosis 6 , 7 , 34 . In this systematic literature review of 18 cases of RPA, it was found that 22.2% progressed to malignant tumors, a rate considered high compared to other studies 7 , 9 , 12 , 38 , probably associated with small tumor sample. The recent retrospective study by Choi et al 14 comparing malignancy and recurrence of pleomorphic adenoma found no evidence that relapse or repeated surgeries promote malignant transformation of the tumor.…”

Section: Discussionmentioning

confidence: 66%

“…Imaging examinations consistently showed a hypodense maxillary lesion, often with well-defined borders, extending into the maxillary sinus, nasal cavity, and orbital cavity. Additionally, bone involvement was also observed 26,27,29,34,36,38 . These clinical features align with descriptions found in other studies of primary pleomorphic adenoma in the palate 3,37 .…”

Section: Discussionmentioning

confidence: 94%

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Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Lopes-Santos,

Marques,

Tjioe

et al. 2024

Acta Cir. Bras.

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Purpose: This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas. Methods: Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor. Results: Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9–73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval – 95%CI 1.13–27.52), and 20 years (OR = 18.78; 95%CI 3.18–110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up. Conclusions: The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 94%

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Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Lopes-Santos,

Marques,

Tjioe

et al. 2024

Acta Cir. Bras.

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“…Apesar de discreta, há uma predileção pelo sexo femininorepresentando cerca de 60% dos casos. 2,3,12 Brazilian Journal of Health Review, Curitiba, v. 7, n. 1, p. 698-709, jan./fev., 2024 Clinicamente, o Adenoma Pleomórfico em palato duro se apresenta como um nódulo com limites bem definidos recoberto por uma mucosa de coloração e aspecto normais, firme à palpação, imóvel e que a depender do tempo de evolução e região, pode desenvolver úlceras no tecido de recobrimento e evoluir para necrose dessa mucosa sobrejacente. Sua evolução geralmente é lenta e indolor com baixo potencial de malignização1, 2, 4.…”

Section: Introductionunclassified

Tratamento cirúrgico de Adenoma Pleomórfico em palato duro em adolescente – relato de caso clínico

Mauro,

Alves,

De Alcântara

et al. 2024

Braz. J. Hea. Rev.

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O Adenoma Pleomórfico é a neoplasia benigna mais comum das glândulas salivares maiores ocorrendo principalmente nas glândulas parótidas e mais raramente, em glândulas salivares menores. Das regiões mais acometidas pelo AP de glândulas salivares menores, o palato é o sítio de maior ocorrência. Clinicamente apresenta-se como um nódulo bem delimitado recoberto por mucosa de coloração e aspecto normais, indolor, de evolução lenta e muitas vezes desapercebido pelo paciente. Os exames de imagem ideais para a avaliação dessa patologia é a tomografia computadorizada e a ressonância magnética. Seu tratamento é baseado na excisão cirúrgica e as taxas de recidiva são baixas. O objetivo deste trabalho foi relatar um caso clínico de Adenoma Pleomórfico em palato duro em uma adolescente de 13 anos tratado com excisão cirúrgica pela equipe de Cirurgia e Traumatologia Bucomaxilofacial do Hospital Regional Sul, e realizar uma revisão de literatura a respeito dessa patologia, com ênfase na faixa etária do caso descrito dada a sua raridade.

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“…According to the World Health Organization, pleomorphic adenoma is a confined tumor, has pleomorphic or mixed epithelial origin characteristics, and is interspersed with mucoid tissue, myxoid tissue, and chondroid masses. It accounts for 66-90% of all salivary gland tumors in children, making it the most typical salivary gland neoplasm [ 8 ]. The preferred course of therapy is wide local excision with removal of the periosteum and affected bone [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

Panchal,

Wanjari

2023

Cureus

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Pleomorphic adenoma affects mostly the parotid gland (85%), submandibular glands (5%), and the minor salivary glands (5%). They are usually referred to as benign mixed tumors because they are composed of both epithelial cells, which are cells from the body's surface, and myoepithelial cells, present inside glands to aid in secretion. An 88-year-old male who had an ulcer for 10 days and a three to four-month-old swelling on his palate arrived in the OPD. On examination, at the intersection of the hard and soft palates, there is a single, well-delineated, nodular exophytic development of small salivary glands left to the median half (most of the pleomorphic adenomas are unilateral). For further and confirmatory diagnosis, fine needle aspiration cytology, immunohistochemistry tests, and radiodiagnosis, i.e., X-rays, were performed which revealed periapical abscess and swelling on palate unassociated with pus discharge. Surgical removal of the swelling and extraction of the root stump was done. The patient was asked to stop smoking strictly. Post-operatively, the patient was given suitable medications.

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Rare Case Report: Young Male Hard Palate Pleomorphic Adenoma

Cited by 4 publications

References 8 publications

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Tratamento cirúrgico de Adenoma Pleomórfico em palato duro em adolescente – relato de caso clínico

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

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