Rare Case Report of Neuroendocrine Tumor in Axilla-Metastasis from Unknown Primary or De Novo?

Dholaria, Shreyas; Lakhera, Kamal Kishor; Patni, Sanjeev

doi:10.1007/s13193-017-0716-4

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…There have been reported incidences of NET arising from breast tissue, abdominal wall and lymph nodes 4–7. In cases with isolated nodal/soft tissue involvement without any primary foci, the possibility of a lymph node-origin tumour based on epithelial inclusions or anomalous carcinomatous differentiation of stem cells of the lymphoreticular system can be considered 4.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumour of the lesser omentum

Babu,

Subbiah Nagaraj,

Yadav

et al. 2023

BMJ Case Rep

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A man in his early 20s presented to us in the outpatient department with a history of diarrhoea for 4 months. Investigations revealed elevated serum chromogranin levels and an intensely avid lesion in the gastrohepatic ligament in Gallium DOTATATE positron emission tomography (PET). The tumour was excised laparoscopically, and no other lesions were seen. The patient improved clinically and had a normal serum chromogranin level postoperatively. He is currently much improved at the 1year follow-up. We did an extensive workup to look for a primary tumour. It was concluded that it was a de novo tumour arising from the lesser sac. The recommended investigations in case of neuroendocrine tumour (NET) with unknown primary include blood investigations to look for the functional status of the tumour, histopathological examination, including immunohistochemistry, and radiological imaging, which must include a Gallium DOTATATE PET. An isolated NET of the lesser sac has not been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumour of the lesser omentum

Babu,

Subbiah Nagaraj,

Yadav

et al. 2023

BMJ Case Rep

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“…The most common sites include the gut, lungs, and bronchi; however, the soft tissue is an uncommon site [ 4 ] and is classified as NETs and neuroendocrine carcinomas (NECs) according to the latest World Health Organization (WHO) edition published in 2019 [ 11 ]. Dholaria et al [ 12 ] reported a case of NEC in the axilla of a man. IHC of this tumor showed positive Syp, and negative for CK7 and CK20, with a high Ki-67 index (80%).…”

Section: Discussionmentioning

confidence: 99%

“…IHC of this tumor showed positive Syp, and negative for CK7 and CK20, with a high Ki-67 index (80%). Therefore, he was diagnosed with NEC and axillary metastasis from an unknown primary or de novo [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Breast neuroendocrine tumor arising in the axilla of a man: a case report

et al. 2022

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Background Accessory breast carcinomas of the axilla of males are rare, and primary breast neuroendocrine tumors (BNETs) are rare as well. We present a case of a BNET arising in the axilla of a man. Case presentation A 64-year-old Japanese man presented with a hard 15-mm mass in the axilla and axillary lymph node swelling. Histopathological examination of the incisional biopsy specimen revealed a neuroendocrine carcinoma. Therefore, wide radical excision of the axillary tumor and axillary lymph node dissection were performed. Hematoxylin and eosin staining showed that the solid tumor was mainly located in the subcutaneous adipose tissues and appeared to invade the skin. The tumor phenotypes were positive for CAM 5.2, synaptophysin, estrogen receptor, progesterone receptor, and GATA-binding protein 3; they were negative for human epidermal growth receptor 2. The neuroendocrine component comprised more than 90% of the tumor, and the Ki-67 index was 21%. These results indicated that the tumor was a BNET. This patient underwent adjuvant chemotherapy, endocrine therapy, and radiotherapy. Conclusions BNET cases in males are rare. The clinical and histological criteria as well as treatment for these rare cases are discussed.

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“…After 4 cycles, a new PET/CT showed partial metabolic response in the axillary mass and complete response of adrenal metastases, marked with blue and green arrows, respectively ( B ). Even NETs can originate from any neuroendocrine cell in the body, them originating in axillary soft tissues is very uncommon, 1–3 and the incidence of lymph node metastasis from an unknown primary NET is also low 4 . NETs commonly overexpress SSTR in grade 1 and 2 tumors; however, some series have demonstrated that grade 3 NET can also have SSTR overexpression in 61.9% of cases 5 .…”

mentioning

confidence: 99%

Neuroendocrine Tumor Presented With Axillary Mass

Sicilia Pozo,

López-Bermejo García,

Ruiz Disotuar

et al. 2024

Clin Nucl Med

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A 79-year-old man presented with a palpable left axillary mass and ultrasonography findings of conglomerate lymph nodes. The initial clinical suspicion was a lymphoproliferative disorder, but histopathological results revealed a grade 3 neuroendocrine tumor. The mass showed somatostatin receptor overexpression in 99mTc-HYNIC-TOC scintigraphy and high uptake in 18F-FDG PET/CT. Bilateral hypermetabolic adrenal nodes suggestive of metastases were also detected. The patient was treated with chemotherapy and immunotherapy, and PET/CT scan showed a partial metabolic response after 4 cycles. According to this case, neuroendocrine tumor should be considered in the differential diagnosis of axillary masses.

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Rare Case Report of Neuroendocrine Tumor in Axilla-Metastasis from Unknown Primary or De Novo?

Cited by 4 publications

References 8 publications

Neuroendocrine tumour of the lesser omentum

Neuroendocrine tumour of the lesser omentum

Breast neuroendocrine tumor arising in the axilla of a man: a case report

Neuroendocrine Tumor Presented With Axillary Mass

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