"Rare Case of Polymicrobial Sepsis with Cupravidus Pauculus in a Sclerodermic Patient"

Abstract

Pleşca, Antoanela Pasare and Olivia Dorneanu. Rare Case of Polymicrobial Sepsis with Cupravidus Pauculus in a Sclerodermic Patient. Biomed J Sci & Tech Res 46(3)-2022. BJSTR. MS.ID.007343.Cupriavidus pauculus (C. pauculus), formerly named Wautersia paucula, is a Gram negative, aerobic, non-fermentative germ with ubiquitous environmental distribution and can cause severe infections in humans. We present the case of a 41 -years old female patient with scleroderma with recent history of travel in Thailand, who was admitted for sepsis with Streptococcus pneumonia, associating a respiratory infection caused by multi-drug resistant germs, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. During hospitalization, respiratory status was aggravated and a non -fermentative germ, namely Cupriavidus pauculus, was identified in sputum samples. The evolution of the patient with an underlying immunocompromised condition after empiric treatment with imipenem, followed by antibiotic therapy selected by susceptibility test (levofloxacin and trimethoprim/sulfamethoxazole) was favourable with recovery after one month of hospitalization. C. pauculus is characterized by a highly variable profile of resistance, including sometimes extended -spectrum antibiotics. Only few reports of infections produced by this pathogen in humans are available. Further data are needed since C. pauculus is responsible for severe infections especially in immunosuppressed patients.