Rare case of orbital tumor

Shyla, P. R.; Nair, Reshmi M.; Somanathan, Thara

doi:10.1007/s12070-007-0052-z

Cited by 3 publications

(1 citation statement)

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“…Reviewing all previous papers, to our knowledge 23 cases of thyroid carcinomas with orbital metastases have previously been described (13)(14)(15)(16)19,21,(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Orbital metastasis from thyroid cancer: a case report and review of the literature

Sapuppo¹,

Martorana²,

Tirr³

et al. 2022

Ann Palliat Med

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Background: Differentiated thyroid cancer (DTC) is generally associated with an excellent prognosis.However up to 20% of DTC patients have disease events during subsequent follow-up; rarely patients present an aggressive disease with distant metastases (DM), mainly in the lung and bone. Metastases at unusual sites may also occur, generally in patients with disseminated disease. Orbital localization is rare and only few cases have been described so far.Case Description: A 36 years-old man, treated with chemo and radiotherapy during childhood for non-Hodgkin lymphoma, was referred for suspicious lymph node (LN) and multiple lung metastases. Total thyroidectomy and latero-cervical (LC) lymphadenectomy were performed: papillary thyroid cancer (PTC), 25 mm, 11/17 LN metastases; pT2N1bM1. Post-treatment total body scan with I-131 showed LN and lung uptake. Eighteen months from diagnosis he presented progressive diplopia, proptosis and right exophthalmos due to an 18 mm orbital metastasis. Hence, due to I-131 refractoriness for structural disease progression despite I-131 therapy, he started therapy with Lenvatinib for 6 months, with initial partial response followed by disease progression, and then with Cabozantinib, which he stopped after 6 months for adverse events and disease progression after therapy reduction. Currently, the patient is receiving Lenvatinib, rechallenge therapy, with disease stabilization and biochemical response. Molecular analysis, performed on both primary and relapsed tumor didn't show any significant pathogenic alteration.Conclusions: This case of DTC with an unusual metastasis in the orbit, may suggest that patient's exposure to chemo-and radiotherapy during pediatric age might have played a role in the subsequent development of this unusually aggressive tumor, reinforcing the recommendation of long-term and intensive follow-up of these patients.

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Section: Discussionmentioning

confidence: 99%

Orbital metastasis from thyroid cancer: a case report and review of the literature

Sapuppo¹,

Martorana²,

Tirr³

et al. 2022

Ann Palliat Med

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Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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BackgroundFollicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.Case presentationA 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. The PubMed database was searched for literature describing thyroid cancer with facial skeleton metastasis using the key words “thyroid,” “cancer,” “carcinoma,” “metastasis,” and “malignancy” with “oral cavity,” “maxilla,” “mandible,” “sinus,” “paranasal,” and “orbit.” Reports that only involved the soft tissues were excluded. Systematic review revealed 59 cases of well-differentiated thyroid cancer with facial skeleton metastasis: 35 mandibular metastases (21 = FTC), 6 maxilla metastases (2 = FTC), 9 orbital metastases (4 = FTC), and 11 paranasal sinus metastases (7 = FTC). Treatment included surgery, RAI, external beam radiotherapy (XRT), or a combination of these modalities. The one, two, and five-year survival rates were 100%, 79%, and 16%, respectively.ConclusionFacial skeleton metastasis of FTC is a rare clinical challenge. Optimal treatment appears to include total thyroidectomy and resection of involved structures with or without adjuvant treatment.

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Thyroid and Eye: Where They Meet in Clinical Practice

El-Eshmawy

Shahin

2020

EMIDDT

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Objective: Thyroid Hormones (TH) are essential for normal growth, development and continued optimal function of most of the body organs including the eye. TH signaling plays a central role in the regulation of retinal development and maturation. Deficiency in TH during fetal and early postnatal development impairs growth of the eye and proliferation of all retinal cell types. The present article reviews the most important topics of the different derangements in thyroid function and structure and its relation with eye diseases. Methods: A literature search strategy was conducted for all English-language literature. Results: From a clinical practice viewpoint, it should be mentioned that both hypothyroidism and hyperthyroidism are accompanied by ocular diseases i.e. thyroid-associated ophthalmopathy, diabetic retinopathy and age-related macular degeneration. Although the orbit and globe are not common sites for metastatic thyroid cancers, orbital metastasis may be the primary clinical manifestation of thyroid carcinoma. Finally, some medications as amiodarone may be accompanied by both thyroid dysfunction and adverse ocular events. Conclusion: Thyroid disorders and eye diseases are interrelated through several mechanisms thus, awareness of this relation has a great impact on early diagnosis and treatment.

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Rare case of orbital tumor

Cited by 3 publications

References 0 publications

Orbital metastasis from thyroid cancer: a case report and review of the literature

Orbital metastasis from thyroid cancer: a case report and review of the literature

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Thyroid and Eye: Where They Meet in Clinical Practice

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