Rare case of conus medullaris syndrome from a metastatic yolk sac tumor originating from the mediastinum of an adult male: a case report and review of the literature

Ajiboye, Remi M.; Nelson, Scott D.; Shamie, Arya Nick

doi:10.14444/2059

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Primary mediastinal YSTs have worse survival compared with other extragonadal YSTs due to the large tumor bulk at diagnosis, resistance to chemotherapy, and difficulty in removing all residual disease after chemotherapy. Early detection and therapy is important because the tumor shows good response to surgery and chemotherapy (8).…”

Section: Discussionmentioning

confidence: 99%

Bir çocukta birincil posterior mediastinal germ hücreli tümör

et al. 2019

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Yolk sac tumor is the most common malignant neoplasm of germ cell origin and usually occurs in infant testes or ovaries. On rare occasions, the tumor arises from extragonadal sites, including the sacrococcygeal region, uterus, vagina, prostate, retroperitoneum, liver, mediastinum (commonly in the anterior), pineal gland, and third ventricle. Yolk sac tumors have an unfavorable prognosis, if not treated aggressively. We report the case of a 3-year-old boy with a primary posterior mediastinal yolk sac tumor who was managed initially with surgery, followed by chemotherapy and had a favorable prognosis. In the literature on yolk sac tumors presenting as a mediastinal mass, pediatric germ cell tumors have been reported very rarely in the posterior mediastinum.

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Section: Discussionmentioning

confidence: 99%

Bir çocukta birincil posterior mediastinal germ hücreli tümör

et al. 2019

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“…Injury or lesions involving the tapered distal end of the spinal cord (T12 through L2) can lead to CMS. Common causes of this syndrome include disk herniation in the lower thoracic and upper lumbar spine, trauma resulting in a compression or burst fracture with retropulsed fragments causing cord compression, intramedullary tumor (metastasis or primary tumor), infection (ie, epidural abscess), spi-nal dural arteriovenous fistulas, and cord infarction (18,33,34,(46)(47)(48)(49). The clinical features of CMS are severe back pain, lower-extremity weakness (mixed UMN and LMN deficit), saddle anesthesia or hypoesthesia (Fig 26), early bladder and rectal sphincter dysfunction, and impotence (18,19).…”

Section: Conus Medullaris Syndromementioning

confidence: 99%

Incomplete Cord Syndromes: Clinical and Imaging Review

et al. 2018

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The ability to localize the three spinal tracts (corticospinal tract, spinothalamic tract, and dorsal [posterior] columns) involved in incomplete spinal cord syndromes at cross-sectional imaging and knowledge of the classic clinical manifestations of the various syndromes enable optimized imaging evaluation and provide clinicians with information that aids in diagnosis and treatment. The requisite knowledge for localizing these tracts is outlined. The authors review the spinal cord anatomy, blood supply, and course of these tracts and describe the various associated syndromes: specifically, dorsal cord, ventral cord, central cord, Brown-Séquard, conus medullaris, and cauda equina syndromes. In addition, they describe the anatomic basis for the clinical manifestation of each syndrome and the relevant imaging features of the classic causes of these entities. Knowledge of the anatomy and clinical findings of the spinal cord is essential for examining and treating patients with cord abnormalities. RSNA, 2018.

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“…6 Across 184 countries, the rate of PTB ranges from 5 to 18% of all babies born. 7,8 The prevalence of PTB is also increasing in developing countries with an alarming level and is up to 12% among all new borns. 9 Almost 15 million infants are born preterm every year around the globe.…”

Section: Introductionmentioning

confidence: 99%

“…More than 60% of PTBs occur in South Asia, SubSaharan Africa, and even in some of the developed countries such as the United States of America. 7 The prevalence of PTB is almost 5% in Europe and 18% in Africa. 8 In Asian region, unfortunately Pakistan has an increasing statistics with 748,100 PTB annually and has fourth highest number after India, China and Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Preterm Birth in Pakistan: A Systematic Review and Meta-Analysis

Hanif¹,

Ashraf²,

Waheed³

et al. 2017

Annals KEMU

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Objective: This study is designed to systematically review the prevalence of preterm birth from previously published studies of Pakistan and to find pooled prevalence from available local data. Methodology:Targeted literature was searched with specific key words such as "preterm birth, prematurity, prevalence and mortality in preterm birth in Pakistan". Studies with copyright and/or permission issues were excluded. A total of 300 studies were found initially that were somewhat related to the topic, after careful screening only 5 studies met inclusion criteria for current study. To test the null hypothesis for all studies evaluating effect Cochran's Q was used and P-values with a level of significance of 5%were considered significant. Results:The pooled prevalence of Preterm Birth was found to be 18.89% using fixed effect, 16.81% using random effect and 18.89% using fixed effect heterogeneity. I-squared for each effect model was > 75%. On applying Chi 2 test we obtained significant p-value i.e. p-value < 0.01. Conclusion: Through this meta-analysis we found one of the highest pooled prevalence of preterm birth in Pakistan. Reducing preterm birth can result in improvement of overall neonatal health and significantly reduce neonatal mortality in future.

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Rare case of conus medullaris syndrome from a metastatic yolk sac tumor originating from the mediastinum of an adult male: a case report and review of the literature

Cited by 5 publications

References 15 publications

Bir çocukta birincil posterior mediastinal germ hücreli tümör

Bir çocukta birincil posterior mediastinal germ hücreli tümör

Incomplete Cord Syndromes: Clinical and Imaging Review

Prevalence of Preterm Birth in Pakistan: A Systematic Review and Meta-Analysis

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