Rare and serious cardiac side effects during ropinirole titration

Cardiac Risks and Guidance Regarding Domperidone: An Ounce of Prevention Is Worth a Pound of Cure

“…Extra care should be taken for those patients who are on concomitant medications able to prolong the QT interval or that inhibit the cytochrome, CYP3A4, including, but not limited to, some drugs commonly used in clinical practice, such as omeprazole and ranitidine, or other medications also frequently used in the parkinsonian population, such as sertraline and high‐dose entacapone. Obviously, domperidone should also be avoided in patients with concomitant cardiac diseases, and, in this regard, it is important to remember that serious cardiac side effects have also been associated with the use of nonergot DAs …”