Rapsyn Antibodies in Myasthenia Gravis<sup>a</sup>

Agius, Mark; Zhu, Shuyu; Kirvan, Christine A.; Schafer, Anne L.; Lin, Mike Y.; Fairclough, Robert H.; Oger, Joél; Aziz, T.; Aarli, Johan A.

doi:10.1111/j.1749-6632.1998.tb10972.x

Cited by 41 publications

(28 citation statements)

References 3 publications

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“…Rapsyn is an intracellular end-plate protein that is necessary for the clustering of AChRs at the postsynaptic folds of the NMJ [97]. Anti-rapsyn antibodies have been found in almost 15% of MG patients, most commonly in thymomatous MG [92], but have also been found in patients with other autoimmune diseases [98].…”

Section: Antibodies To Non-achr Nmj Proteinsmentioning

confidence: 99%

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Meriggioli¹,

Sanders

2012

Expert Review of Clinical Immunology

145

108

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Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. A number of molecules, including ion channels and other proteins at the neuromuscular junction, may be targeted by autoantibodies leading to abnormal neuromuscular transmission. In approximately 85% of patients, autoantibodies, directed against the postsynaptic nicotinic acetylcholine receptor can be detected in the serum and confirm the diagnosis, but in general, do not precisely predict the degree of weakness or response to therapy. Antibodies to the muscle-specific tyrosine kinase are detected in approximately 50% of generalized myasthenia gravis patients who are seronegative for anti-acetylcholine receptor antibodies, and levels of anti-muscle-specific tyrosine kinase antibodies do appear to correlate with disease severity and treatment response. Antibodies to other muscle antigens may be found in the subsets of myasthenia gravis patients, potentially providing clinically useful diagnostic information, but their utility as relevant biomarkers (measures of disease state or response to treatment) is currently unclear.

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Section: Antibodies To Non-achr Nmj Proteinsmentioning

confidence: 99%

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Meriggioli¹,

Sanders

2012

Expert Review of Clinical Immunology

145

108

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“…Such antibodies have been shown to react with the muscle antigens titin [6], ryanodine receptor (RyR) [7], and probably also other muscle proteins [8][9][10]. Assays for non-AChR antibodies against undefined muscle antigens have been widely used in MG diagnosis.…”

Section: Introductionmentioning

confidence: 98%

Muscle autoantibodies in subgroups of myasthenia gravis patients

et al. 2000

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Myasthenia gravis (MG) is caused by autoantibodies to the acetylcholine receptor (AChR), but several other muscle autoantibodies have also been identified in patient sera. We studied muscle autoantibodies against AChR, striated muscle tissue sections (SH), titin, citric acid antigen (CA), and ryanodine receptor (RyR) in sera from 146 consecutive MG patients to evaluate whether a single test or several tests together can predict a thymoma. The MG patients were divided into five subgroups; ocular MG, early-onset MG (< 50 years), late-onset MG (> 50 years), MG with thymoma, and AChR antibody negative MG. AChR, SH, titin, CA, and RyR antibodies were detected in 85%, 34%, 34%, 25%, and 14% of the MG patients, respectively. For thymoma MG, AChR, SH, titin, CA, and RyR antibodies were detected in 100%, 75%, 95%, 70%, and 70% respectively. SH, titin, CA, RyR antibodies, and computed tomography of the anterior mediastinum have similar sensitivity for thymoma MG. The specificity of RyR, titin, CA, and SH antibodies for thymoma was 70%, 39%, 38%, and 31%, respectively, which is significantly higher for RyR antibodies than for the others. No single muscle antibody assay can predict a thymoma, and a combination of several antibody assays is preferred, although RyR antibody testing alone showed 70% sensitivity and specificity for thymoma MG. SH and CA antibodies provided only little additional information.

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“…hand, the appearance of AB to rapsyn is not specific for myasthenia [4]. No AB to any of ACR subunits were detected in patients with endocrine ophthalmopathy and healthy controls.…”

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confidence: 65%

Differential Diagnosis of Various Forms of Myasthenia and Endocrine Ophthalmopathy by Immunoblotting

Lantsova

Sepp

2005

Bull Exp Biol Med

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Immunoblotting can be used for screening a population of antibodies to acetylcholine receptor subunits circulating in the blot of patients with myasthenia. Torpedo Californica acetylcholine receptor served as the antigen. We found that in generalized myasthenia autoantibodies bind to alpha1- or alpha1- and gamma-subunits, while in ophthalmic form they bind only gamma-subunit of acetylcholine receptor. No antibodies to any of the acetylcholine receptor subunits were detected in patients with endocrine ophthalmopathy and in healthy volunteers. This method can be used for differential diagnosis of ophthalmic myasthenia and endocrine ophthalmopathy and for predicting generalization of the pathological process in patients with myasthenia.

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Rapsyn Antibodies in Myasthenia Gravis^a

Cited by 41 publications

References 3 publications

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Muscle autoantibodies in subgroups of myasthenia gravis patients

Differential Diagnosis of Various Forms of Myasthenia and Endocrine Ophthalmopathy by Immunoblotting

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Rapsyn Antibodies in Myasthenia Gravisa

Cited by 41 publications

References 3 publications

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Muscle autoantibodies in subgroups of myasthenia gravis patients

Differential Diagnosis of Various Forms of Myasthenia and Endocrine Ophthalmopathy by Immunoblotting

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Product

Resources

About

Rapsyn Antibodies in Myasthenia Gravis^a