Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16–20 October 2015

Abstract

The XXIIIrd World Congress of Psychiatric Genetics (WCPG) meeting, sponsored by the International Society of Psychiatric Genetics (ISPG), was held in Toronto, ON, Canada, on October 16-20, 2015. Approximately 700 participants attended to discuss the latest state-of-the-art findings in this rapidly advancing and evolving field. The following report was written by trainee travel awardees. Each was assigned one session as a rapporteur. This manuscript represents the highlights and topics that were covered in the plenary sessions, symposia, and oral sessions during the conference, and contains major notable and new findings.

Stress dynamically regulates co-expression networks of glucocorticoid receptor-dependent MDD and SCZ risk genes

“…This suggests that alterations in stress-induced changes of endocytosis could contribute to disease risk by altering neuronal activity. For example, glutamate receptor turnover has been shown to be altered by glucocorticoid-induced enhancement of ubiquitin/proteasome-mediated degradation of receptor subunits 37 , a process localized to late endosomes and multivesicular membranes 38,39 . Pathway analyses revealed enrichment for cytoplasmic ribosomal proteins; ribosomal protein have been shown to be altered both in postmortem gene expression studies for MDD and SCZ 36 , as well as in pluripotent stem cell-derived neural progenitor cells 40 or olfactory-derived neuroepithelial cells 41 from patients with SCZ.…”