Rapidly regulated genes are intron poor

Jeffares, Daniel C.; Penkett, Christopher J.; Bähler, Jürg

doi:10.1016/j.tig.2008.05.006

Cited by 362 publications

(277 citation statements)

References 24 publications

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“…The obtained results are in a good accordance with the results presented in [3], where structural features of genes expressed in stress conditions in yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe), thale cress (Arabidopsis thaliana) and mice (Mus musculus) were examined. The most significant of all the identified effects in the article was that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities across all the examined organisms.…”

Section: Mean Values Of Characteristics P-valuesupporting

confidence: 89%

“…That's why it is coherent to expect the presence of some selection pressure for shortening or against elongation of genes (of course, this pressure could be compensated by the opposite tendency related to other functional reasons). Besides, the energy value required for the subsequent cutting out of the untranslatable nucleotides does not depend on the length of the introns but only on their amount [3]. Therefore, one could additionally assume that selection pressure is acting for intron loss or against intron gain.…”

Section: Introductionmentioning

confidence: 99%

“…The relative compactness of highly expressed human genes was demonstrated in a number of works [3,[6][7][8][9]. Such genes revealed to be shorter and to have fewer introns than the average.…”

Section: Introductionmentioning

confidence: 99%

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Structural Pecularities of Human Genes Which Expression Increases in Response to Stress

Riabenko¹,

Tonevitsky²,

Tonevitsky³

et al. 2011

Am. J. Biomed. Sci.

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We studied structural peculiarities of 123 human genes which were previously identified as genes of early response to exercise stress. Compared to protein-coding genes in general, their structure revealed some peculiarities: they are shorter in both coding and non-coding regions and contain fewer introns. This result is in good agreement with the similar results reported for stress-responding genes in other species (yeasts, thale cress, and mice).

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Section: Mean Values Of Characteristics P-valuesupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Structural Pecularities of Human Genes Which Expression Increases in Response to Stress

Riabenko¹,

Tonevitsky²,

Tonevitsky³

et al. 2011

Am. J. Biomed. Sci.

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show abstract

“…Finally, dynamic cellular processes, such as cellularization (Guilgur et al, 2014) and tracheal branching, which involve rapid regulation of gene expression, may depend more acutely on efficient mRNA processing. Consistent with this idea, highly expressed and rapidly regulated genes tend to have only few and short introns (CastilloDavis et al, 2002;Jeffares et al, 2008).…”

Section: Discussionmentioning

confidence: 89%

Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila

et al. 2017

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Morphogenesis requires the dynamic regulation of gene expression, including transcription, mRNA maturation and translation. Dysfunction of the general mRNA splicing machinery can cause surprisingly specific cellular phenotypes, but the basis for these effects is not clear. Here, we show that the Drosophila faint sausage (fas) locus, which is implicated in epithelial morphogenesis and has previously been reported to encode a secreted immunoglobulin domain protein, in fact encodes a subunit of the spliceosomeactivating Prp19 complex, which is essential for efficient pre-mRNA splicing. Loss of zygotic fas function globally impairs the efficiency of splicing, and is associated with widespread retention of introns in mRNAs and dramatic changes in gene expression. Surprisingly, despite these general effects, zygotic fas mutants show specific defects in tracheal cell migration during mid-embryogenesis when maternally supplied splicing factors have declined. We propose that tracheal branching, which relies on dynamic changes in gene expression, is particularly sensitive for efficient spliceosome function. Our results reveal an entry point to study requirements of the splicing machinery during organogenesis and provide a better understanding of disease phenotypes associated with mutations in general splicing factors.

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“…27 In Saccharomyces cerevisiae, Schizosaccharomyces pombe, Arabidopsis thaliana, and Mus musculus, genes that rapidly change their expression levels in response to stress were found to have significantly fewer and shorter introns. 28 Severe stress, like elevated temperature, puts cells at risk. Rapid expression of responding genes, like heat shock proteins (Hsp), is crucial to cell survival.…”

Section: Introductionmentioning

confidence: 99%

Higher frequency of intron loss from the promoter proximally paused genes ofDrosophila melanogaster

Jiang

Li²,

Niu³

2014

Fly

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Rapidly regulated genes are intron poor

Cited by 362 publications

References 24 publications

Structural Pecularities of Human Genes Which Expression Increases in Response to Stress

Structural Pecularities of Human Genes Which Expression Increases in Response to Stress

Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila

Higher frequency of intron loss from the promoter proximally paused genes ofDrosophila melanogaster

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