Rapidly Progressive Thyroid Mass

İbrahimov, Metin; Yılmaz, Mehmet; Kılıç, Erdem; Akıl, Ferit; Rasidov, Resul; Karaman, Emin

doi:10.1097/scs.0b013e31825cef34

Cited by 6 publications

(13 citation statements)

References 3 publications

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“…Amyloid goitre is defined as the deposition of amyloid in the glandular parenchyma, such as to determine a volumetric enlargement, clinically evident, and atrophy of thyroid follicles [ [14] , [15] , [16] ].…”

Section: Discussionmentioning

confidence: 99%

A rare case of primary thyroid amyloidosis

Cannizzaro¹,

Bianco

Saliba³

et al. 2018

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

A rare case of primary thyroid amyloidosis

Cannizzaro¹,

Bianco

Saliba³

et al. 2018

International Journal of Surgery Case Reports

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“…‘Amyloid goiter’ is the deposition of amyloid in the glandular parenchyma of the thyroid gland causing a clinically apparent enlargement [ 1 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Amyloid goiter - A rare case report and literature review

Lari

Burhamah

Lari

et al. 2020

Annals of Medicine and Surgery

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Introduction Amyloid goiter is a rare presentation of thyroid swelling, which occurs with either primary or secondary amyloidosis. This condition must be differentiated from other types of goiters or malignancies. Even though the thyroid is extensively involved by amyloid, patients are usually euthyroid, but many different presentations and overlaps have been reported. Currently the treatment is surgical resection of the thyroid gland Case presentation We report a case of a 53-year-old previously healthy male who presented with a 2 year history of a progressively enlarging painless neck swelling. The patient was euthyroid and denied any associated symptoms. The patient subsequently underwent an uneventful total thyroidectomy along with an unremarkable follow up and was diagnosed with primary amyloidosis involving only the thyroid gland confirmed by histopathology. Discussion and conclusion Amyloid goiter is a rare entity; a high index of suspicion is required in patients with an enlarging thyroid gland and a concomitant history of chronic inflammatory processes or plasma cell dyscrasia. FNA biopsy should be performed to exclude the top differential of primary thyroid malignancy. Thyroidectomy is necessary for definitive diagnosis and symptom relief. Every effort should be made to delineate the extent of the disease, and in those previously healthy plasma cell dyscrasia should be excluded

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“…Even though the thyroid gland involvement by amyloid is relatively common, clinically signi cant enlargement of the thyroid due to amyloid deposition is extremely rare, and most of the cases are not diagnosed before surgery [2][3]. Although there is no effective medical therapy for amyloid goiter, there are current regimens to treat amyloid by chemotherapy [1][2][3]. Here, in this case, we report a 37-old-year gentleman known case of osteopetrosis and now diagnosed as amyloid goiter after diagnostic hemithyroidectomy with a pre-operative clinical diagnosis of suspicious of papillary thyroid carcinoma.…”

Section: Introductionmentioning

confidence: 99%

An unilateral rapidly growing amyloid goiter associated with osteopetrosis: a Case Report and Literature Review

Jeladharan

Singh

Jat

et al. 2023

Preprint

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Introduction: Amyloid goiter of the thyroid is a rare disorder characterized by the deposition of amyloid proteins within the thyroid gland, leading to its enlargement and functional impairment. The exact cause of amyloid goiter remains unknown, but it is associated with multiple myeloma, systemic amyloidosis, and familial Mediterranean fever. Diagnosis is made through imaging studies and histological examination of thyroid tissue. Treatment options include observation, thyroid hormone replacement therapy, and surgical resection, depending on the extent of thyroid enlargement and functional impairment. Prognosis is generally favorable, but it depends on the underlying cause of amyloid deposition and the extent of thyroid involvement. Case Presentation: We report a case of a 37-year-old previously healthy male who presented with a history of progressively enlarging painless neck swelling for 2-3 months. The patient was euthyroid and denied any associated symptoms. The patient subsequently underwent an uneventful hemithyroidectomy along with an unremarkable postoperative period. Histopathology examination and special stains revealed the diagnosis of amyloid goiter. Conclusions: A strong index of suspicion is necessary in patients with an enlarged thyroid gland and a concurrent history of chronic inflammatory processes or plasma cell dyscrasia because amyloid goitre is a rare condition. The present case is unique and unusual since there is no record in the literature of an amyloid goitre being associated with osteopetrosis in a patient. To get a conclusive diagnosis and to get rid of symptoms, a thyroidectomy is required. For the diagnosis of this uncommon entity, a histopathological study is crucial. Every effort should be taken to determine the full scope of the illness, and plasma cell dyscrasia should be ruled out in people who were previously healthy.

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Rapidly Progressive Thyroid Mass

Cited by 6 publications

References 3 publications

A rare case of primary thyroid amyloidosis

A rare case of primary thyroid amyloidosis

Amyloid goiter - A rare case report and literature review

An unilateral rapidly growing amyloid goiter associated with osteopetrosis: a Case Report and Literature Review

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