Rapidly progressive glomerulonephritis due to systemic lupus erythematosus and ANCA-associated vasculitis overlap

Farah, Randa; Shahin, Nisreen Abu; Alawneh, Mohannad; Adwan, Marwan H.

doi:10.1177/0961203320920368

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…The known cases of overlap syndrome have primarily occurred in young women with an average age of 40 who present with new-onset kidney failure or rapidly progressive glomerulonephritis [3]. The organ most frequently involved in the overlap between SLE and AAV is the kidney, although any organ or system can be involved [9,10]. Other common clinical manifestations include articular and cutaneous features, but hematologic, pulmonary, cardiac, and ENT manifestations can also be present [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Subarachnoid Hemorrhage in Autoimmune Vasculitis: A Rare Presentation of Systemic Lupus Erythematosus-Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Overlap Syndrome

Palleti¹,

Larson²,

Avula³

et al. 2023

Cureus

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Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), though they share similar clinical characteristics, are distinguishable based on specific characteristics. The concomitant presentation of SLE and AAV as overlap syndrome is rare and makes the diagnosis challenging. Here, we describe a rare case of SLE and AAV overlaps presenting with hemorrhagic stroke as initial presentation, which has been reported only once before. The presence of several positive autoantibodies made the diagnosis challenging, but a kidney biopsy provided the definitive diagnosis and aided in initiating immunosuppressive therapy. The patient did not respond to standard initial surgical measures to lower elevated intracranial pressure and showed significant improvement to immunosuppressive therapy proving the temporal relationship. The authors of this case study aim to highlight the importance of considering SLE-AAV overlap in patients presenting with features similar to those described in the case report and intervening early, as delays in diagnosis can be fatal.

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Section: Discussionmentioning

confidence: 99%

Subarachnoid Hemorrhage in Autoimmune Vasculitis: A Rare Presentation of Systemic Lupus Erythematosus-Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Overlap Syndrome

Palleti¹,

Larson²,

Avula³

et al. 2023

Cureus

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“…SLE and AAV are autoimmune diseases that can share clinical characteristics such as arthritis, skin lesions, and kidney involvement. In many cases, the two diseases can be distinguished by clinical characteristics, antibody profile, and kidney disease, but some patients may have mixed patterns including classification criteria for both SLE and AAV, called SLE/AAV overlap syndrome 26 , 27 .…”

Section: Discussionmentioning

confidence: 99%

Anca-positive vasculitis with full-house nephropathy, an unusual association: a case report and review of literature

et al. 2022

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Rapidly progressive glomerulonephritis is a medical emergency, with mortality around 20%. It is characterized by crescent glomerulonephritis and progressive loss of kidney function, hematuria, and proteinuria. Its classification is given by immunofluorescence detection of antibodies against glomerular basement membrane (Anti-MBG), immunocomplexes, or pauci-immune pattern. Its etiology should be based on clinical findings, immunological profile, age, sex, and histopathological characteristics. We present a case of a 27-year-old woman with symptoms consistent with rapidly progressive glomerulonephritis and biopsy findings of a full-house kidney nephropathy, with an early fatal outcome. An association of low incidence, as it is a case with a full-house pattern, and an autoimmune profile for negative systemic lupus erythematosus makes this a rare case. ANCA-associated vasculitis with full-house kidney disease was diagnosed, an unusual condition with up to 3% presentation and few reports in the literature, highlighting the importance of its reporting and contribution to the literature.

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Systemic lupus erythematosus and antineutrophil cytoplasmic antibodies-associated vasculitis overlap in an elderly woman: A case-based literature review

Sulaiman

Foong

Tan³

et al. 2022

The Egyptian Rheumatologist

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Rapidly progressive glomerulonephritis due to systemic lupus erythematosus and ANCA-associated vasculitis overlap

Cited by 5 publications

References 10 publications

Subarachnoid Hemorrhage in Autoimmune Vasculitis: A Rare Presentation of Systemic Lupus Erythematosus-Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Overlap Syndrome

Subarachnoid Hemorrhage in Autoimmune Vasculitis: A Rare Presentation of Systemic Lupus Erythematosus-Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Overlap Syndrome

Anca-positive vasculitis with full-house nephropathy, an unusual association: a case report and review of literature

Systemic lupus erythematosus and antineutrophil cytoplasmic antibodies-associated vasculitis overlap in an elderly woman: A case-based literature review

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