Rapidly progressive dementia with false-positive PCR Tropheryma whipplei in CSF. A case of Hashimoto's encephalopathy

Robles-Cedeño, René; Gich, Jordi; Batlle, David Genís; Ramió-Torrentà, Ll

doi:10.1016/j.jns.2015.05.043

Cited by 5 publications

(6 citation statements)

References 13 publications

(13 reference statements)

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“…After following the inclusion and exclusion criteria and removing duplicates, a total of forty articles describing 46 cases were identified. These reports varyingly described one, [12,14,15,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][33][34][35][36][38][39][40][41][42][43][44][45][46][47][48][49] two, [32,37,50] or a maximum of three cases. [13,16] Table 1 summarizes the age and gender distribution of the cases included for review.…”

Section: Resultsmentioning

confidence: 99%

“…[13,16,32,49] A diagnosis of schizophrenia was made in one case. [42] Five reports described patients with paroxysmal nocturnal amnesia, [33] mixed anxiety-depression, [36] vitamin B12-related neuroanemic syndrome, [24] generalized anxiety disorder, [20] and conversion disorder, [23] respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the sample (n = 28,60.9%) had not been diagnosed with hypothyroidism. [12][13][14]16,17,19,20,[25][26][27][28]32,34,36,39,[41][42][43][46][47][48][49][50] In four cases, the antithyroglobulin (TG) titer was within normal limits, [32,40,49,50] but wherever the antithyroperoxidase (TPO) titer was available, it was noted to be elevated. Overall, the mean anti-TPO titers were also much higher than anti-TG titers.…”

Section: Resultsmentioning

confidence: 99%

“…[16] The electroencephalographic findings showed a normal record in nine patients (19.6%) [17,19,20,23,35,37,46,47] while the most common abnormality noted was an intermittent or diffuse background slowing mostly in the frontal and temporal leads with or without bursts of sharp wave discharge (n = 25.54.3%). [12][13][14]16,18,20,24,[26][27][28][32][33][34]36,39,[41][42][43][44][45]49,50] Magnetic resonance imaging (MRI) returned normal study in 26 patients (56.5%). [14,15,16,17,20,21,[23][24][25][26][27][28]31,32,[36][37][38][39]…”

Section: Resultsmentioning

confidence: 99%

“…[12][13][14]16,18,20,24,[26][27][28][32][33][34]36,39,[41][42][43][44][45]49,50] Magnetic resonance imaging (MRI) returned normal study in 26 patients (56.5%). [14,15,16,17,20,21,[23][24][25][26][27][28]31,32,[36][37][38][39][41][42][43][44]46,48,50] Of the others whose imaging data were available, the single most common abnormality reported were nonspecific white matter hyperintense lesions (n = 9.19.6%). [12,13,19,32,…”

Section: Resultsmentioning

confidence: 99%

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Psychiatric Presentations Heralding Hashimoto’s Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature

Menon

Subramanian

Thamizh

2017

Journal of Neurosciences in Rural Practice

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Hashimoto's encephalopathy (HE) may often present initially with psychiatric symptoms. These presentations are often variable in clinical aspects, and there has been no systematic analysis of the numerous psychiatric presentations heralding an eventual diagnosis of HE which will guide clinicians to make a correct diagnosis of HE. This systematic review was done to analyze the demographic characteristics, symptom typology, and clinical and treatment variables associated with such forerunner presentations. Electronic databases such as PubMed, ScienceDirect, and Google Scholar databases were searched to identify potential case reports that described initial psychiatric presentations of HE in English language peer-reviewed journals. The generated articles were evaluated and relevant data were extracted using a structured tool. We identified a total of forty articles that described 46 cases. More than half of the total samples (54.4%) were above the age of 50 years at presentation. The most common psychiatric diagnosis heralding HE was acute psychosis (26.1%) followed by depressive disorders (23.9%). Dementia (10.9%) and schizophrenia (2.2%) were uncommon presentations. Antithyroid peroxidase antibodies were elevated in all patients but not antithyroglobulin antibodies. Preexisting hypothyroidism was absent in majority of cases (60.9%). Steroid doses initiated were 500–1000 mg of intravenous methylprednisolone for majority (52.1%) of patients while oral steroid maintenance was required for a significant minority (39.1%). Psychiatric manifestations of HE may be heterogeneous and require a high index of clinical suspicion, especially in older adults. A range of clinical and treatment variables may assist clinicians in making a faster diagnosis and instituting prompt and effective management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Psychiatric Presentations Heralding Hashimoto’s Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature

Menon

Subramanian

Thamizh

2017

Journal of Neurosciences in Rural Practice

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Hashimoto encephalopathy: a literature review and case report with comprehensive neuropsychological evaluation

Schenck,

McCracken,

Andrasik

et al. 2024

The Clinical Neuropsychologist

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Neuropsychological impairment in Hashimoto’s encephalopathy: A case report and literature review

Sabbah-Talasazan

Piryatinsky

2017

Applied Neuropsychology: Adult

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Hashimoto's encephalopathy (HE) is a rare neurological syndrome characterized by the presence of positive serum antithyroid antibodies, altered mental status, and clinical response to glucocorticoid therapy. Although HE has been documented in the literature from a medical standpoint, reports on the neuropsychological presentation of this syndrome are scarce. This article presents a literature review of cognitive deficits reported in HE cases. In addition, we describe the case of a 76-year-old Russian speaking woman diagnosed with HE in May 2012. MRIs from her disease course and treatment are presented. Posttreatment neuropsychological testing revealed intact attention and construction and impairment in working memory, processing speed, learning, executive functioning, language, and bilateral fine motor dexterity, all of which impacted her functional abilities. Her profile was inconsistent with the typical dementia process. This case demonstrates the utility of neuropsychological assessment for understanding cognitive and functional consequences of HE. The issue of differential diagnosis with dementia is also discussed.

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Rapidly progressive dementia with false-positive PCR Tropheryma whipplei in CSF. A case of Hashimoto's encephalopathy

Cited by 5 publications

References 13 publications

Psychiatric Presentations Heralding Hashimoto’s Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature

Psychiatric Presentations Heralding Hashimoto’s Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature

Hashimoto encephalopathy: a literature review and case report with comprehensive neuropsychological evaluation

Neuropsychological impairment in Hashimoto’s encephalopathy: A case report and literature review

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