Rapidly progressive dementia and ataxia in an elderly man

Hálmagyi, G. Michael; Rodriguez, Michael

doi:10.1136/practneurol-2012-000443

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…First, LM may have also occurred on the cerebral surface, leading to cognitive decline. Tumor cells on the cerebral subarachnoid space may cause microinfarctions due to intracapillary infiltration via Virchow-Robin spaces, and tumor cells may lead to a metabolic competition of the underlying neuronal tissue, resulting in neuronal dysfunction and subsequent cognitive decline [ 19 , 20 ]. In our patient, the initial and only MRI did not show any findings suggestive of LM of the cerebral surface.…”

Section: Discussionmentioning

confidence: 99%

Band-Like Brainstem Lesion in a Patient With a History of Lung Adenocarcinoma

Obara¹

2022

Cureus

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Leptomeningeal metastasis (LM) is a severe complication of primary malignancy that has spread to the leptomeninges and cerebrospinal fluid (CSF). Here, we report a patient whose magnetic resonance imaging (MRI) showed a unique brainstem lesion suspicious of LM. A 72-year-old man presented with dizziness, gait instability, and cognitive decline, primarily object naming. He had a history of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation. Brain MRI revealed a band-like lesion surrounding the ventral brainstem with T2 weighted-image/fluid attenuation inversion recovery (FLAIR) imaging and diffusion-weighted imaging (DWI) hyperintensity without gadolinium enhancement. No malignant cells were detected in the CSF. He underwent ventriculoperitoneal shunt two months after the onset, and his gait improved, but his cognitive function declined further. Recent reports suggest similar brainstem lesions as a unique LM pattern, which occurs almost exclusively in patients with lung adenocarcinoma with EGFR mutation. Therefore, if MRI shows this brainstem finding, repeated and appropriate CSF cytology is needed to detect tumor cells. Furthermore, if a patient with lung adenocarcinoma shows a cognitive decline, cerebral LM and auto-antibodies that mainly target neuronal surface antigens should be considered.

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Section: Discussionmentioning

confidence: 99%

Band-Like Brainstem Lesion in a Patient With a History of Lung Adenocarcinoma

Obara¹

2022

Cureus

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“…Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) or Huntington’s disease (HD), are caused by the formation of inclusion bodies and protein aggregates, or the deposition of abnormal proteins in neuronal cells, which finally lead to degeneration and selective neuronal vulnerability in specific brain regions 1 2 3 . As neurons cannot reproduce or replace themselves when they were damaged or died, progressive degeneration of structures and functions of neurons will cause problems in both physical movement (ataxias) and mental functions (dementias) 4 . Recent researches have revealed the increased formation of autophagic vacuoles in the dopaminergic neurons of PD model 5 , which suggested the possible correlation between autophagy and neurodegenerative diseases.…”

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confidence: 99%

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins

Zeng

Liu

et al. 2015

Sci Rep

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With its traditional use in relieving insomnia and anxiety, our previous study has identified onjisaponin B from Radix Polygalae (RP), as a novel autophagic enhancer with potential neuroprotective effects. In current study, we have further identified a novel active fraction from RP, contains 17 major triterpenoid saponins including the onjisaponin B, by the combinational use of cell membrane chromatography (CMC) and ultra-performance liquid chromatography coupled to (quadrupole) time-of-flight mass spectrometry {UHPLC-(Q)TOF-MS}. By exhibiting more potent autophagic effect in cells, the active fraction enhances the clearance of mutant huntingtin, and reduces protein level and aggregation of α-synuclein in a higher extent when compared with onjisaponin B. Here, we have reported for the first time the new application of cell-based CMC and UHPLC-(Q)TOF-MS analysis in identifying new autophagy inducers with neuroprotective effects from Chinese medicinal herb. This result has provided novel insights into the possible pharmacological actions of the active components present in the newly identified active fraction of RP, which may help to improve the efficacy of the traditional way of prescribing RP, and also provide new standard for the quality control of decoction of RP or its medicinal products in the future.

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Rapidly progressive dementia and ataxia in an elderly man

Cited by 2 publications

References 48 publications

Band-Like Brainstem Lesion in a Patient With a History of Lung Adenocarcinoma

Band-Like Brainstem Lesion in a Patient With a History of Lung Adenocarcinoma

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins

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