Rapidly Progressive Acute Retinal Necrosis Secondary to Herpes Simplex Virus, Type 1

Duker, Jay S.; Nielsen, J C; Eagle, Ralph C.; Bosley, Thomas M.; Granadier, Robert; Benson, William E.

doi:10.1016/s0161-6420(90)32356-4

Cited by 69 publications

(25 citation statements)

References 30 publications

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“…Other investigators have shown the zosteriform spread of HSV-1 during acute ocular infection involves the TG, requiring replication in the nervous system rather than corneal tissue (51). Clinically, HSV-1 infection of the retina, known as acute retinal necrosis syndrome, is a relatively rare disease presenting with vitritis and progressive retinal necrosis (17,32). Experimentally, HSV-1 has been reported to infect the contralateral retina via the brain following anterior chamber inoculation (1).…”

Section: Discussionmentioning

confidence: 99%

Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection

Carr

Chodosh

Ash

et al. 2003

J Virol

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The inflammatory response to acute ocular herpes simplex virus type 1 (HSV-1) infection in mice involves the innate and adaptive immune response, with an associated increase in the secretion of chemokines, including CXCL10 (interferon-inducible protein 10 kDa [IP-10]). Neutralizing antibodies to mouse CXCL10 were used to determine the role of CXCL10 during the acute phase of HSV-1 ocular infection. Treatment of HSV-1-infected mice with antibody to CXCL10 significantly reduced CXCL10 levels in the eye and trigeminal ganglion and reduced mononuclear cell infiltration into the corneal stroma. These results coincided with reduced ICAM-1 and CXCR3 transcript expression, macrophage inflammatory protein-1␣ and CXCL10 levels, and corneal pathology but increased viral titers in the stroma and trigeminal ganglion. Progression of the virus from the corneal stroma to the retina during acute infection was significantly hindered in anti-CXCL10-treated mice. In addition, colocalization of viral antigen with infiltrating leukocytes in the iris and retina during acute infection suggests that one means by which HSV-1 traffics to the retina involves inflammatory cells (primarily CD11b ؉ cells). Collectively, the results suggest that CXCL10 expression in the eye initially orchestrates the inflammatory response to acute HSV-1 infection, which facilitates the spread of the virus to other restricted sites within the eye.

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Section: Discussionmentioning

confidence: 99%

Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection

Carr

Chodosh

Ash

et al. 2003

J Virol

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“…Patients may have a history of previous systemic disease, such as herpes simplex or zoster dermatitis, but by no means is this a matter of course [8,9]. In immunocompromised patients, lesions of suspected viral origin do not always bear the hallmarks of well-characterized clinical syndromes, such as ARN or cytomegalovirus (CMV) retinopathy, and these lesions have been categorized together under the designation "necrotizing herpetic retinopathies" [10].…”

mentioning

confidence: 99%

“…For this reason, cultures of samples from the virtually cell-free aqueous and vitreous compartments are negative; therefore, such means cannot be used to establish viral etiology [9,11,12]. However, analysis of paired aqueous and serum samples for the existence of specific antibodies has led to successful diagnoses in 65% of cases [13][14][15]; if this procedure is carried out on a sequential basis, 72%-86% of cases may be successfully diagnosed [16].…”

mentioning

confidence: 99%

Varicella-Zoster Virus Is Strongly Associated with Atypical Necrotizing Herpetic Retinopathies

Garweg

Böhnke

1997

Clinical Infectious Diseases

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Aqueous humor samples from nine patients with atypical necrotizing retinopathies of suspected viral origin, six with acute retinal necrosis syndrome (ARN), and 17 with active cytomegalovirus (CMV) retinitis underwent amplification for viral DNA of herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and human CMV. VZV DNA was detected in seven of the nine aqueous humor samples from patients with atypical necrotizing retinopathies of suspected viral origin and in four of the six samples from individuals with ARN; of the two other samples from patients with ARNS, no viral DNA was found in one, and both CMV DNA and HSV-1 DNA, but not VZV DNA, were detected in one (this patient presented with bilateral ARNS 2 months after being successfully treated for CMV retinitis). Thus, VZV is likely to be the main pathogen of atypical necrotizing herpetic retinopathies. DNA amplification may be used to establish an early, sensitive, and reliable diagnosis of any form of necrotizing retinopathy in 80% of cases, irrespective of viral etiology.

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“…Uma das explicações para o resultado positivo seria por se tratar de um caso de infecção primária pelo vírus herpes simples, enquanto nas reativações esse achado torna-se mais difícil, devido aos baixos títulos séricos (8) . Neste caso, a VVPP foi essencial para o diagnósti-co, pela observação da retina com aspecto necrótico e oclusão vascular difusa.…”

Section: Discussionunclassified

Necrose retiniana aguda por presumível etiologia viral por herpes simples resultando em endoftalmite: relato de caso

Tanaka¹,

Fonseca²,

Helal³

2011

Rev. bras.oftalmol.

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RESUMOA necrose retiniana aguda é uma rara e devastadora retinite necrotizante, que pode ser causada pelo vírus herpes simples tipo 1 ou 2. Afeta tipicamente pacientes saudáveis de todas as idades. Este estudo é um relato de caso de um paciente de 18 anos, previamente hígido, que apresentou necrose aguda de retina por presumível etiologia viral por herpes simples, e descreve sua apresentação clínica e ultrassonográfica. Por não ter sido diagnosticado e tratado precocemente, a necrose retiniana aguda cumpriu sua história natural e evoluiu para um quadro compatível com endoftalmite.

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Rapidly Progressive Acute Retinal Necrosis Secondary to Herpes Simplex Virus, Type 1

Cited by 69 publications

References 30 publications

Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection

Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection

Varicella-Zoster Virus Is Strongly Associated with Atypical Necrotizing Herpetic Retinopathies

Necrose retiniana aguda por presumível etiologia viral por herpes simples resultando em endoftalmite: relato de caso

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