Rapidly Growing Mycobacterial Infections of the Skin and Soft Tissues Caused by M. fortuitum and M. chelonae

González-Díaz, Esteban; Morfín‐Otero, Rayo; Pérez-Gómez, Héctor Raúl; Esparza-Ahumada, Sergio; Noriega, Eduardo Rodríguez

doi:10.1007/s40475-018-0150-x

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…Commonly, the incubation period lasts around 2–8 weeks, although several cases have been reported with 2–4 months or longer (6–8 months) incubation times [ 63 , 64 ]. More systemic respiratory and extra-respiratory diseases are rare, but can occur, especially in immunocompromised patients [ 17 , 65 , 66 , 67 ].…”

Section: Zoonotic Considerationmentioning

confidence: 99%

Mycobacteriosis and Infections with Non-tuberculous Mycobacteria in Aquatic Organisms: A Review

2020

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The Mycobacteriaceae constitute a family of varied Gram-positive organisms that include a large number of pathogenic bacteria. Among these, non-tuberculous mycobacteria are endemic worldwide and have been associated with infections in a large number of organisms, including humans and other mammals and reptiles, as well as fish. In this review, we summarize the most recent findings regarding this group of pathogens in fish. There, four species are most commonly associated with disease outbreaks: Mycobacterium marinum, the most common of these fish mycobacterial pathogens, Mycobacterium fortuitum, Mycobacterium gordonae, and Mycobacterium chelonae. These bacteria have a broad host range: they are zoonotic, and infections have been reported in a large number of fish species. The main route of entry of the bacterium into the fish is through the gastrointestinal route, and the disease is associated with ulcerative dermatitis as well as organomegaly and the development of granulomatous lesions in the internal organs. Mycobacteriaceae are slow-growing and fastidious and isolation is difficult and time consuming and diagnostic is mostly performed using serological and molecular tools. Control of the disease is also difficult: there is currently no effective vaccine and infections react poorly to antibiotherapy. For this reason, more research is needed on the subject of these vexing pathogens.

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Section: Zoonotic Considerationmentioning

confidence: 99%

Mycobacteriosis and Infections with Non-tuberculous Mycobacteria in Aquatic Organisms: A Review

2020

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“…In addition, M. fortuitum and M. chelonae were identified in water samples collected from freshwater rivers, ponds, and brooks in Iran by Rahbar et al in 2010 using isolation on Lowenstein–Jensen (LJ) medium [ 48 ]. Notably, these species have a potential to infect fish (farmed and wild fish) [ 27 , 28 ] and humans [ 24 ]. Likewise, Mycobacterium spp.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, more systemic forms of mycobacteriosis can also occur, including those which involve the respiratory system particularly in immunocompromised patients [ 5 , 23 ]. Additionally, other NTM such as M. chelonae , M. fortuitum , M. flavescens , and M. gordonae have also been associated with granulomatous lesions, hepatitis, endocarditis, and meningitis, and infections have been observed in the ocular, bone, joint, and skeletal system [ 19 , 21 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…M. gordonae has similarly been reported from several fish species including Gold fish ( Carassius auratus ), Guppy ( Poecilia reticulate ), Angel fish ( Pterophyllum scalare ), and Common carp ( Cyprinus carpio ) [ 26 ]. Additionally, M. fortuitum and M. chelonae have both been reported in the ornamental and wild fish, including Neon tetra ( Paracheirodon innesi ), Goldfish ( Carassius auratus auratus ), Three-spot gourami ( Trichogaster trichopterus ), Cichlid fish ( Microgeophagus altispinosus ), Sterlet ( Acipenser ruthenus ), Siamese fighting fish ( Betta splendens ), Dwarf gourami ( Colisa lalia ), Sailfin molly ( Poecilia latipinna ), Giant sailfin molly ( Poecilia velifera ), Discus fish ( Symphysodon discus ), Green swordtail ( Xiphophorus helleri ), Australian lungfish ( Neoceratodus fosteri ), Silver mullet ( Mugil curema ), Atlantic salmon ( Salmo salar ), and juvenile Pacific salmon ( Oncorhynchus tshawytscha ) [ 16 , 24 , 27 , 28 , 29 , 30 , 31 ]. M. marinum is an important bacterial agent causing fish tuberculosis, and transmission to humans can be observed via contaminated water in aquarium and fish breeding.…”

Section: Introductionmentioning

confidence: 99%

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Identification Mycobacterium spp. in the Natural Water of Two Austrian Rivers

et al. 2020

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Nontuberculous mycobacteria constitute a subgroup among the Mycobacterium genus, a genus of Gram-positive bacteria that includes numerous pathogenic bacteria. In the present study, Mycobacterium spp. were detected in natural water samples from two Austrian rivers (Kamp and Wulka) using three different primers and PCR procedures for the identification of the 16S rRNA and hsp65 genes. Water samples were collected from the Kamp (45 samples) and Wulka (25 samples) in the summer and winter of 2018 and 2019. Molecular evidence showed a high prevalence of Mycobacterium sp. in these rivers with prevalence rates estimated at approximately 94.3% across all rivers. The present study represents the first survey into the prevalence of Mycobacterium sp. in natural water in Austria. Because nontuberculous mycobacteria have known pathogenic potential, including zoonotic, these findings may have implications for health management and public health.

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“…M. fortuitum infection is recognized as a nosocomial infection, which can affect many areas of the body, including the skin [ 4 ], lymph nodes [ 5 ], lungs [ 6 ], and bones (osteomyelitis), especially after a catheterization surgery [ 7 , 8 ]. The M. fortuitum group consists of about 15 fast-growing NTM species.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic delivery evaluation against Mycobacterium fortuitum using nanofluids containing carbon nanotubes

et al. 2022

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Background Mycobacterium fortuitum (M. fortuitum) is a bacterium, which can cause infections in many anatomical regions of the body, including the skin, lymph nodes, and joints. This bacterium, which belongs to a group of bacteria known as nontuberculous mycobacteria, is regarded as an important nosocomial pathogen worldwide owing to its increasing antibiotic resistance. Recently, the antimicrobial effects of carbon nanotubes have been reported in numerous studies. These nanotubes can be very useful in drug delivery; besides, they exhibit unique properties against multidrug-resistant bacterial infections. This study aimed to investigate the antimicrobial effects of carboxyl-functionalized multi-walled carbon nanotubes (MWCNT-COOH) to reduce antibiotic resistance. Methods In this study, antibacterial effects of nanofluids containing functionalized MWCNTs at initial concentration of 2 mg/mL and serial dilutions of 54, 28.5, 14.25, 7.12, 3.5 µg/mL, antibiotics alone and combination of nanofluids with antibiotics were investigated. Standard and resistant strains of M. fortuitum were obtained from the microbial bank of the Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran. Results It was observed that nanofluid containing MWCNT-COOH can exert antimicrobial effects on M. fortuitum and significantly reduce bacterial resistance to antibiotics including kanamycin and streptomycin. In the presence of antibiotics and nanofluids containing MWCNT-COOH at a dose of 28.5 µg/mL, no growth was observed. Conclusion One of the main antimicrobial mechanisms of MWCNT-COOH is penetration into the bacterial cell wall. In this study, by using the nanofluid containing MWCNT-COOH with increased stability, the antibiotic resistance of M. fortuitum was significantly reduced at lower dilutions compared to the antibiotic alone.

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Rapidly Growing Mycobacterial Infections of the Skin and Soft Tissues Caused by M. fortuitum and M. chelonae

Cited by 8 publications

References 57 publications

Mycobacteriosis and Infections with Non-tuberculous Mycobacteria in Aquatic Organisms: A Review

Mycobacteriosis and Infections with Non-tuberculous Mycobacteria in Aquatic Organisms: A Review

Identification Mycobacterium spp. in the Natural Water of Two Austrian Rivers

Antibiotic delivery evaluation against Mycobacterium fortuitum using nanofluids containing carbon nanotubes

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