Rapidly growing intrathoracic extraskeletal Ewing's sarcoma

Abstract

There are few reported cases of intrathoracic Ewing's sarcoma, a very rare malignant neoplasm. We report a surgical case of extraskeletal Ewing's sarcoma that had been followed-up as a stable sized tumour for many years, which then grew rapidly within a year. A 27-year old female patient with a rapidly growing abnormal shadow on chest roentgenogram was admitted to our department. She had undergone periodic examinations including chest computed tomography (CT) scans for 6 years since a small nodule in her chest had been pointed out by chest roentgenogram. The initial CT demonstrated a solitary nodule with a diameter of 20 mm on the parietal pleura that covered the V rib of the posterior chest wall. For 5 years the tumour's size did not change noticeably but it suddenly grew to about 90 mm diameter in a year. The tumour volume doubling time was calculated to be 17 days.

Rapidly Growing Chest Wall Lipoma: Case Report and Calculating Volume Doubling Time

“…In addition to morphological features, many patients with liposarcoma have a chronological feature of rapid growth, and TVDT has been investigated (18)(19)(20)(21). It should be noted that most of the numerical values are calculated based on Schultz formula (18)(19)(20)(21), assuming that the tumor grows while maintaining a nearly spherical shape. It is presumed that TVDT varies depending on the degree of differentiation, malignancy, and site of occurrence (20,21).…”

“…It should be noted that most of the numerical values are calculated based on Schultz formula (18)(19)(20)(21), assuming that the tumor grows while maintaining a nearly spherical shape. It is presumed that TVDT varies depending on the degree of differentiation, malignancy, and site of occurrence (20,21). Median TVDT for liposarcoma has been reported in several case reports, ranging from eight to 25 days, and generally less than 200 days (18)(19)(20)(21).…”

“…It is presumed that TVDT varies depending on the degree of differentiation, malignancy, and site of occurrence (20,21). Median TVDT for liposarcoma has been reported in several case reports, ranging from eight to 25 days, and generally less than 200 days (18)(19)(20)(21). On the other hand, in the report that measured the TVDT for lipoma, as far as we could search in the literature, there was only one case of primary r enal angiomyolipoma, and the TVDT was 231-675 days (22).…”