Rapidly Growing Endocrine Cell Carcinoma of the Colon with Elevated Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF-C: A Case Report

BACKGROUND Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs; these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach; however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC.

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Colorectal neuroendocrine carcinoma: A case report and review of the literature

Yoshida

Kamimura

Hosaka

et al. 2019

WJCC

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Bevacizumab併用mFOLFOX6療法が奏効した上行結腸内分泌細胞癌の１例

KUGIMIYA

Kobayashi

Shigeta

et al. 2012

Yamaguchi Medical Journal

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Cecal Adenoendocrine Cell Carcinoma Presented with Right Inguinal Lymph Node Metastasis Yields Complete Response to mFOLFOX6 and Bevacizumab:A Case Report

Mukai¹,

Fukunaga²,

Ikeda³

et al. 2013

Journal of Japan Society of Coloproctology

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Rapidly Growing Endocrine Cell Carcinoma of the Colon with Elevated Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF-C: A Case Report

Cited by 6 publications

References 17 publications

Colorectal neuroendocrine carcinoma: A case report and review of the literature

Colorectal neuroendocrine carcinoma: A case report and review of the literature

Bevacizumab併用mFOLFOX6療法が奏効した上行結腸内分泌細胞癌の１例

Cecal Adenoendocrine Cell Carcinoma Presented with Right Inguinal Lymph Node Metastasis Yields Complete Response to mFOLFOX6 and Bevacizumab:A Case Report

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