Rapidly disintegrating tablets prepared by the wet compression method: Mechanism and optimization

Abstract

To make rapidly disintegrating tablets with sufficient mechanical integrity, tablets were prepared by compressing wet granules under low compression force and then drying the resulting wet mass in a circulating-air oven (wet compression method). Lactose with various particle sizes was used as the excipient, and water was used as a wetting agent. The effect of drying time, compression force, size of lactose particles, and moisture content of wet granules on tablet properties indicated that the formation and disintegration time of tablets were related to the effect of the formation of solid bridges between lactose particles. By optimizing compression force, size of lactose particles, and moisture content of the granules, tablets meeting tensile strength greater than 0.5 MPa and disintegration time shorter than 15 s were obtained by the wet compression method.

Potential Use of 2-Hydroxypropyl-.BETA.-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl-.ALPHA.-Tocopheryl Acetate, an Oily Drug

“…This solid bridge is known to be the product of lactose crystal formed by recrystallization during a drying process, depending on the solubility of lactose in suspension. 29) However, the number of the pores and the pore space between particles decreased as the content of HP-b-CyD increased (Fig. 7B).…”

Formulation and Evaluation of Flurbiprofen Fast Disintegrating Tablets Using Natural Superdisintegrants

“…These dosage forms dissolve or disintegrate in oral cavity within a minute without the need of water or chewing. FDT's are not only useful in administration of drugs in pediatric and geriatric patients but also in patients suffering from dysphasia and are ideal for active people as well [1,2]. These dosage forms show good stability, ease of manufacture, and ease of handling by patients.…”

Effects of Water Yam and Corn Starches on the Interacting Variables Influencing the Disintegration of Chloroquine Phosphate Tablets

“…Ideally, disintegrants should cause the tablet to disrupt, not only into the granules from which it was compressed, but also into powder particles from which the granulation was prepared. 2 There are three major mechanisms of tablet disintegration: swelling, porosity and capillary action (Wicking) and deformation. 3 Although not all effective disintegrants swell when in contact with water, swelling is believed to be a mechanism in which certain disintegrants such as starch impart their effect.…”