Rapidly Developing Nephrocalcinosis in a Patient With End-Stage Liver Disease Who Received a Domino Liver Transplant From a Patient With Known Congenital Oxalosis

Aziz, Seerat; Vincenti, Flavio; Hirose, Ryutaro

doi:10.7863/jum.2005.24.10.1449

Cited by 11 publications

(10 citation statements)

References 10 publications

(14 reference statements)

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“…Our subjects were highly selected for normality and may represent unusually healthy liver. Comparison with age‐matched hyperoxalosis normal liver tissue, often used in domino liver transplantation,32‐38 vindicated this approach, as there was no discernible difference in telomere length between the groups.…”

Section: Discussionmentioning

confidence: 99%

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

et al. 2012

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Telomeres, a validated biomarker of aging, comprise multiple nucleotide repeats capping chromosomes that shorten with each cell cycle until a critical length is achieved, precipitating cell senescence. Only two previous studies focused on the effect of aging in ''normal'' liver tissue, but these studies were compromised by small sample size, limited age range, tissue derived from individuals with an increased risk of senescence, and the use of liver homogenates. We developed a robust large-volume, four-color quantitative fluorescent in situ hybridization technique to measure telomere length in large numbers of hepatocytes, Kupffer cells, hepatic stellate cells, CD4-positive and CD8-positive lymphocytes, and cholangiocytes. Following validation against the gold standard (Southern blotting), the technique was applied to normal archived paraffin-embedded liver tissue obtained following reperfusion of implanted donor liver. We studied 73 highly selected donors aged 5-79 years with a short medical illness preceding death and no history of liver disease, reperfusion injury, or steatosis and normal graft function 1-year posttransplantation. Cholangiocytes had significantly longer telomeres compared with all other intrahepatic lineages over a wide age range (P < 0.05). Age-related telomere attrition was restricted to sinusoidal cells (i.e., Kupffer cells [P 5 0.0054] and stellate cells [P 5 0.0001]). Cholangiocytes and hepatocytes showed no age-related telomere shortening. Conclusion: In normal liver and over a broad age range, cholangiocytes have longer telomeres than all other intrahepatic lineages. Age-related telomere length decline is restricted to Kupffer cells and stellate cells. (HEPATOLOGY 2012;56:1510-1520

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Section: Discussionmentioning

confidence: 99%

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

et al. 2012

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“…Patients who receive livers from donors with PH can develop renal failure as early as 4 weeks after transplantation. Of 9 reported cases, 3 required dialysis, 4 died, and 2 underwent retransplantation with improvement in renal failure . As PH may manifest at almost any age—from birth to the sixth decade of life—an unaffected donor could theoretically transmit the disease to their relatives with LDLT.…”

Section: Primary Hyperoxaluriamentioning

confidence: 99%

“…However, both the donor and recipient developed severe hyperammonemia postoperatively, likely under the stress of LT. Urine samples from both demonstrated high levels of orotic acid confirming the diagnosis of OTCD. The recipient then deteriorated neurologically and Genetic cholestatic disorders GS (18)(19)(20) DJS (21) Thrombotic diseases AT deficiency (10) Protein C deficiency (11) Factor V Leiden (13,14) Protein S deficiency (15) ITP (132)(133)(134)(135)(136) Urea cycle disorders OTCD (4,5) Bleeding disorders Hemophilia A (123) Hemophilia B (124,125) Factor VII deficiency (122) Factor XI deficiency (126,(128)(129)(130) Food allergies (138,(140)(141)(142) Maple syrup urine disease (24,25,67,69) PH (29)(30)(31)(32)70) HH (6)(7)(8) CF (34) A1AT deficiency (35,36,79) PCLD (40)…”

Section: Urea Cycle Disordersmentioning

confidence: 99%

Genetic, hematological, and immunological disorders transmissible with liver transplantation

Tan¹,

Florman

Schiano

2017

Liver Transpl

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It is well recognized that solid organ transplantation can transmit bacterial infection and chronic viral hepatitis as well as certain cancers. As indications for liver transplantation (LT) have expanded, it has been used to treat and even cure certain genetic cholestatic disorders, urea cycle defects, and coagulation abnormalities; many of these conditions are potentially transmissible with LT as well. It is important for clinicians and transplant patients to be aware of these potentially transmissible conditions as unexplained post-LT complications can sometimes be related to donor transmission of disease and thus should prompt a thorough exploration of the donor allograft history. Herein, we will review the reported genetic, metabolic, hematologic, and immunological disorders that are transmissible with LT and describe clinical scenarios in which these cases have occurred, such as in inadvertent or recognized transplantation of a diseased organ, domino transplantation, and with living related liver donation. Liver Transplantation 23 663-678 2017 AASLD.

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“…Examples that might be detectable by pathologists include various cancers, amyloidosis, hemochromatosis, fungal, viral, and parasitic diseases [15]. Metabolic diseases, such as familial amyloid polyneuropathy [16], oxalosis [17], and possibly α 1 -antitrypsin deficiency [18] can be intentionally or unintentionally transferred with the donor organ in "domino" transplants.…”

Section: Deceased Donor Biopsy Evaluationmentioning

confidence: 99%

“…Liver transplantation can transmit diseases such as familial amyloidosis, polyneuropathy [16], and oxalosis [17] when these genetically diseased, but phenotypically normal, livers are used as "domino" transplants. centage of untreated HBV-positive recipients will develop confluent/ bridging, and even submassive necrosis, especially if IS is rapidly reduced [192].…”

Section: Hepatitis Virus Infectionsmentioning

confidence: 99%

Histopathological Syndromes of Liver Allograft Rejection and Recurrent Disease

Demetris

Minervini

Nalesnik

et al. 2014

Textbook of Organ Transplantation

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Rapidly Developing Nephrocalcinosis in a Patient With End-Stage Liver Disease Who Received a Domino Liver Transplant From a Patient With Known Congenital Oxalosis

Cited by 11 publications

References 10 publications

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

Genetic, hematological, and immunological disorders transmissible with liver transplantation

Histopathological Syndromes of Liver Allograft Rejection and Recurrent Disease

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